CD3D - CD3 delta subunit of T-cell receptor complex Gene

Homo sapiens

Also known as T3D; IMD19; CD3DELTA; CD3-DELTA

Gene ID: 915 | Gene type: protein coding

About CD3D

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,338,954-118,342,705 (from NCBI)

This gene has 8 transcripts (splice variants), 146 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 30.2), appendix (RPKM 14.7) and 9 other tissues.

Summary

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four Other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

CD3D Products(2)

mRNA	Protein	Name
NM_000732.6	NP_000723.1	T-cell surface glycoprotein CD3 delta chain isoform A precursor
NM_001040651.2	NP_001035741.1	T-cell surface glycoprotein CD3 delta chain isoform B precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	14967045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	8176201	GOA
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	9485181	GOA
part of alpha-beta T cell receptor complex	IPI IPI: Inferred from physical interaction	31461748	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	31461748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD3D Protein Structure

ITAM

0
100
171 a.a.

Protein Preferred Names

Protein Names

T-cell surface glycoprotein CD3 delta chain

CD3 antigen, delta subunit

CD3D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD3D	P04234	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CD3D	P04234	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	CD3D	P04234	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD3D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7879	CD3D Protein, Human (HEK293, His)	P04234 (F22-A105)	≥95%
HY-P70434	CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His)	P04234 (F22-A105)&P07766 (D23-D126)	≥95%
HY-P72726	CD3D-CD3E Heterodimer Protein, Human (HEK293, His)	P04234 (F22-A105)&P07766 (D23-D126)	≥95%
HY-P73498	CD3D-CD3E Heterodimer Protein, Human (HEK293, Flag-His)	P04234 (F22-A105)&P07766 (D23-D126)	≥95%
HY-P74301	CD3D-CD3E Heterodimer Protein, Human (HEK293)	P04234 (F22-A105)&P07766 (D23-D126)	≥95%
HY-P77610	CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥95%
HY-P77612	CD3D-CD3E Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta

T-B+ Scid Due To Cd3delta/Cd3epsilon/Cd3zeta

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Immunodeficiency 18

IMD18	Cd3-Epsilon Deficiency
Immunodeficiency 18, Scid Variant	Cd3epsilon Deficiency
Immunodeficiency 18, Severe Combined Immunodeficiency Variant	Immunodeficiency, Type 18

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Cd3zeta Deficiency

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Coronin-1a Deficiency

Adenosine Deaminase Deficiency

Ada Deficiency	Ada-Scid
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency	Adenosine Deaminase Deficient Severe Combined Immunodeficiency
Scid Due To Ada Deficiency	Severe Combined Immunodeficiency Due To Ada Deficiency
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency	Ada
Scid Due To Adenosine Deaminase Deficiency

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Bare Lymphocyte Syndrome, Type Ii

Mhc Class Ii Deficiency	Bare Lymphocyte Syndrome
Major Histocompatibility Complex Class Ii Deficiency	Bare Lymphocyte Syndrome 2
Bare Lymphocyte Syndrome Type 2	Severe Combined Immunodeficiency, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group C	Bare Lymphocyte Syndrome, Type Ii, Complementation Group D
Bare Lymphocyte Syndrome Type Ii	Scid, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group A	Bare Lymphocyte Syndrome, Type Ii, Complementation Group B
Scid Due To Absent Class Ii Hla Antigens	Hla Class 1 Deficiency
Scid, Hla Class 2-Negative	Bls Type Ii
Bare Lymphocyte Syndrome Type 2, Complementation Group A	Bare Lymphocyte Syndrome Type 2, Complementation Group E
Severe Combined Immunodeficiency	Bls, Type Ii
Bls	Bare Lymphocyte Syndrome, Type Ii, Complementation Group E
Blsii	Bls Type 1
Bls 2	Scid Due To Absence Of Class Ii Hla Antigens
Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens	Immunodeficiency By Defective Expression Of Mhc Class Ii
BLS2	Bare Lymphocyte Syndrome Type Ii Complementation Group A
Bare Lymphocyte Syndrome Type Ii Complementation Group B	Bare Lymphocyte Syndrome Type Ii Complementation Group C
Bare Lymphocyte Syndrome Type Ii Complementation Group D	Bare Lymphocyte Syndrome Type Ii Complementation Group E
Bls Ii	Hereditary Mhc Class Ii Deficiency
Hla Class Ii Deficient Combined Immunodeficiency	Mhc-Ii Deficiency
Scid Hla Class Ii-Negative	Severe Combined Immunodeficiency Hla Class Ii-Negative
Bl-2	Immunodeficiency By Defective Expression Of Hla Class 2
Hla Class 2-Negative Severe Combined Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02242	CD3D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD3D	VGNC	VGNC:107436
Felis catus	CD3D	VGNC	VGNC:60616
Rattus norvegicus	CD3D	RGD	RGD:2304
Bos taurus	CD3D	VGNC	VGNC:27028
Canis familiaris	CD3D	VGNC	VGNC:38954
Mus musculus	CD3D	MGD	MGI:88331
Macaca fascicularis	CD3D	NCBI	NCBI:102133701
Others	CD3D	NCBI

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