CENPL - centromere protein L Gene

Homo sapiens

Also known as CENP-L; C1orf155; dJ383J4.3

Gene ID: 91687 | Gene type: protein coding

About CENPL

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,799,550-173,824,883 (from NCBI)

This gene has 10 transcripts (splice variants) and 203 orthologues. Broad expression in testis (RPKM 4.2), bone marrow (RPKM 2.4) and 22 other tissues.

Summary

CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

CENPL Products(13)

mRNA	Protein	Name
NM_001127181.3	NP_001120653.1	centromere protein L isoform 1
NM_001171182.2	NP_001164653.1	centromere protein L isoform 2
NM_001387284.1	NP_001374213.1	centromere protein L isoform 1
NM_001387285.1	NP_001374214.1	centromere protein L isoform 1
NM_001387286.1	NP_001374215.1	centromere protein L isoform 1
NM_001387287.1	NP_001374216.1	centromere protein L isoform 2
NM_001387288.1	NP_001374217.1	centromere protein L isoform 2
NM_001387289.1	NP_001374218.1	centromere protein L isoform 2
NM_001387290.1	NP_001374219.1	centromere protein L isoform 2
NM_001387291.1	NP_001374220.1	centromere protein L isoform 3
NM_001387292.1	NP_001374221.1	centromere protein L isoform 4
NM_001387293.1	NP_001374222.1	centromere protein L isoform 4
NM_033319.4	NP_201576.1	centromere protein L isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPL Protein Structure

CENP-L

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

centromere protein L

interphase centromere complex protein 33

Related Diseases

Diseases

Alias

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Villous Adenocarcinoma

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02484	CENPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CENPL	VGNC	VGNC:70990
Canis familiaris	CENPL	VGNC	VGNC:39107
Rattus norvegicus	CENPL	RGD	RGD:1311868
Bos taurus	CENPL	VGNC	VGNC:27180
Mus musculus	CENPL	MGD	MGI:1917704
Felis catus	CENPL	VGNC	VGNC:60757

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