CD3G - CD3 gamma subunit of T-cell receptor complex Gene

Homo sapiens

Also known as T3G; IMD17; CD3GAMMA; CD3-GAMMA

Gene ID: 917 | Gene type: protein coding

About CD3G

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,344,344-118,355,161 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues.

Summary

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

CD3G Products(1)

mRNA	Protein	Name
NM_000073.3	NP_000064.1	T-cell surface glycoprotein CD3 gamma chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	14967045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transmembrane signaling receptor activity	IMP IMP: Inferred from mutant phenotype	12794121	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12407027	GOA
involved in establishment or maintenance of cell polarity	IMP IMP: Inferred from mutant phenotype	12407027	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	12794121	GOA
involved in regulation of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	12407027	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	9485181	GOA
part of alpha-beta T cell receptor complex	IPI IPI: Inferred from physical interaction	31461748	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	31461748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD3G Protein Structure

ITAM

0
100
182 a.a.

Protein Preferred Names

Protein Names

T-cell surface glycoprotein CD3 gamma chain

CD3g antigen, gamma polypeptide (TiT3 complex)

CD3G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD3G	P09693	KTN1	Homo sapiens	Q86UP2-3	Validated Y2H	32296183
Intra	CD3G	P09693	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
Intra	CD3G	P09693	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	CD3G	P09693	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
Intra	CD3G	P09693	MAL	Homo sapiens	P21145	Validated Y2H	32296183
Intra	CD3G	P09693	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	CD3G	P09693	TMEM19	Homo sapiens	Q96HH6	Y2H Prey Pooling	32296183
Intra	CD3G	P09693	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	CD3G	P09693	TMEM19	Homo sapiens	Q96HH6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD3G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77609	CD3E-CD3G Heterodimer Protein, Human (HEK293, His)	P07766 (D23-E120)&P09693 (Q23-Q106)	≥95%
HY-P77611	CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc)	P07766 (D23-D126)&P09693 (Q23-S116)	≥95%
HY-P77613	CD3E-CD3G Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi)	P07766 (D23-D126)&P09693 (Q23-S116)	≥95%
HY-P78753	CD3 gamma Protein, Human (HEK293, Fc)	P09693 (Q23-S116)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Immunodeficiency 18

IMD18	Cd3-Epsilon Deficiency
Immunodeficiency 18, Scid Variant	Cd3epsilon Deficiency
Immunodeficiency 18, Severe Combined Immunodeficiency Variant	Immunodeficiency, Type 18

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

Cd3zeta Deficiency

Lymphopenia

Lymphocytopenia

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02244	CD3G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990698	Umizortamig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD3G	MGD	MGI:88333
Canis familiaris	CD3G	VGNC	VGNC:38957
Rattus norvegicus	CD3G	RGD	RGD:1307718
Felis catus	CD3G	VGNC	VGNC:60617
Bos taurus	CD3G	VGNC	VGNC:27031
Macaca mulatta	CD3G	VGNC	VGNC:100904
Macaca fascicularis	CD3G	NCBI	NCBI:102134381
Others	CD3G	NCBI

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