ARRDC4 - arrestin domain containing 4 Gene

Homo sapiens

Gene ID: 91947 | Gene type: protein coding

About ARRDC4

Cytogenetic location: 15q26.2 Genomic coordinates (GRCh38): 15:97,960,703-97,973,833 (from NCBI)

This gene has 1 transcript (splice variant), 165 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 14.4) and 25 other tissues.

Summary

Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARRDC4 Products(1)

mRNA	Protein	Name
NM_183376.3	NP_899232.2	arrestin domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23236378	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	28594402	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	28594402	GOA
acts upstream of or within positive regulation of ubiquitin-protein transferase activity	IPI IPI: Inferred from physical interaction	23236378	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	28594402	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	23236378	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23236378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRDC4 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

arrestin domain-containing protein 4

ARRDC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARRDC4	Q8NCT1	AVPR2	Homo sapiens	P30518	Anti Tag CoIP	23236378

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome	Aarrs
Limb/Pelvis-Hypoplasia/Aplasia Syndrome	LPHAS
Schinzel Type Phocomelia	Absence Of Ulna And Fibula With Severe Limb Deficiency
Al-Awadi/Raas-Rothschild Syndrome	Al Awadi-Raas-Rothschild Syndrome
Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome	Aplasia/Hypoplasia Of Limbs And Pelvis
Congenital Absence Of Ulna And Fibula	Severe Limb Deficit
Phocomelia, Schinzel Type	Al-Awadi-Raas-Rothschild Syndrome
Ulna And Fibula Absence Of With Severe Limb Deficiency	Limb Pelvis Hypoplasia Aplasia Syndrome
Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome	Ulna And Fibula, Absence Of, With Sever Limb Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122682	SBI-993		98.67%	Unkown
HY-124418	SBI-477		≥98.0%	Unkown
HY-RS01033	ARRDC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARRDC4	VGNC	VGNC:107995
Rattus norvegicus	ARRDC4	RGD	RGD:1311763
Canis familiaris	ARRDC4	VGNC	VGNC:38141
Mus musculus	ARRDC4	MGD	MGI:1913662
Bos taurus	ARRDC4	VGNC	VGNC:26174
Felis catus	ARRDC4	VGNC	VGNC:59946

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