MTSS2 - MTSS I-BAR domain containing 2 Gene

Homo sapiens

Also known as ABBA; ABBA1; IDDOF; ABBA-1; MTSS1L

Gene ID: 92154 | Gene type: protein coding

About MTSS2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,661,204-70,686,053 (from NCBI)

This gene has 3 transcripts (splice variants), 277 orthologues and 1 paralogue. Broad expression in brain (RPKM 49.9), endometrium (RPKM 14.9) and 19 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in activation of GTPase activity and cellular response to platelet-derived growth factor stimulus. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

MTSS2 Products(1)

mRNA	Protein	Name
NM_138383.3	NP_612392.1	protein MTSS 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	20875796	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	20875796	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	20875796	GOA
involved in cellular response to platelet-derived growth factor stimulus	IDA IDA: Inferred from direct assay	20875796	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ruffle membrane	IDA IDA: Inferred from direct assay	20875796	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTSS2 Protein Structure

IMD

0
200
400
600
747 a.a.

Protein Preferred Names

Protein Names

protein MTSS 2

MTSS1-like protein

MTSS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTSS2	Q765P7	SCAF1	Homo sapiens	Q9H7N4	Validated Y2H	32296183
Intra	MTSS2	Q765P7	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	32296183
Intra	MTSS2	Q765P7	ALAS1	Homo sapiens	P13196	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Ocular Anomalies And Distinctive Facial Features

IDDOF

Hypotonia

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08821	MTSS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MTSS2	VGNC	VGNC:43494
Macaca mulatta	MTSS2	VGNC	VGNC:75019
Rattus norvegicus	MTSS2	RGD	RGD:1309731
Felis catus	MTSS2	VGNC	VGNC:63661
Mus musculus	MTSS2	MGD	MGI:3039591
Bos taurus	MTSS2	VGNC	VGNC:31753

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