SCAF1 - SR-related CTD associated factor 1 Gene

Homo sapiens

Also known as SRA1

Gene ID: 58506 | Gene type: protein coding

About SCAF1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,640,465-49,658,642 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 11.1), brain (RPKM 11.1) and 25 other tissues.

Summary

Enables RNA polymerase II C-terminal domain binding activity. Predicted to be involved in RNA splicing; mRNA processing; and transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SCAF1 Products(1)

mRNA	Protein	Name
NM_021228.3	NP_067051.2	splicing factor, arginine/serine-rich 19

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II C-terminal domain binding	IPI IPI: Inferred from physical interaction	15992770	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

splicing factor, arginine/serine-rich 19

SCAF

SCAF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCAF1	Q9H7N4	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	MTSS2	Homo sapiens	Q765P7	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	MTSS2	Homo sapiens	Q765P7	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	CIB1	Homo sapiens	Q99828	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	RTN4IP1	Homo sapiens	Q8WWV3	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	RTN4IP1	Homo sapiens	Q8WWV3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia, Autosomal Recessive 3

SCAR3	Scabd
Autosomal Recessive Spinocerebellar Ataxia Type 3	Autosomal Recessive Spinocerebellar Ataxia-Blindness-Deafness Syndrome
Autosomal Recessive Spinocerebellar Ataxia-Blindness-Hearing Loss Syndrome	Spinocerebellar Ataxia With Blindness And Deafness
Autosomal Recessive Spinocerebellar Ataxia 3	Spinocerebellar Ataxia Autosomal Recessive 3
Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness	Autosomal Recessive Cerebellar Ataxia-Blindness-Deafness Syndrome

Pituitary Adenoma 3, Multiple Types

PITA3	Pituitary Adenoma 3, Multiple Types, Somatic
Pituitary Adenoma 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12474	SCAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SCAF1	MGD	MGI:2141980
Bos taurus	SCAF1	VGNC	VGNC:34313
Macaca mulatta	SCAF1	VGNC	VGNC:77137
Canis familiaris	SCAF1	VGNC	VGNC:45888
Rattus norvegicus	SCAF1	RGD	RGD:708405

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