MRRF - mitochondrial ribosome recycling factor Gene

Homo sapiens

Also known as RRF; MRFF; MTRRF

Gene ID: 92399 | Gene type: protein coding

About MRRF

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:122,264,882-122,331,337 (from NCBI)

This gene has 12 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 8.8), duodenum (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]

MRRF Products(8)

mRNA	Protein	Name
NM_001173512.3	NP_001166983.1	ribosome-recycling factor, mitochondrial isoform 3 precursor
NM_001346339.2	NP_001333268.1	ribosome-recycling factor, mitochondrial isoform 4
NM_001346341.2	NP_001333270.1	ribosome-recycling factor, mitochondrial isoform 1 precursor
NM_001346343.2	NP_001333272.1	ribosome-recycling factor, mitochondrial isoform 5
NM_001346345.2	NP_001333274.1	ribosome-recycling factor, mitochondrial isoform 6
NM_001346347.2	NP_001333276.1	ribosome-recycling factor, mitochondrial isoform 7
NM_138777.5	NP_620132.1	ribosome-recycling factor, mitochondrial isoform 1 precursor
NM_199177.4	NP_954646.1	ribosome-recycling factor, mitochondrial isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	19716793	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	18782833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRRF Protein Structure

RRF

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

ribosome-recycling factor, mitochondrial

ribosome-releasing factor, mitochondrial

MRRF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MRRF	Q96E11	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	MRRF	Q96E11	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	32296183
Intra	MRRF	Q96E11	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	MRRF	Q96E11	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	MRRF	Q96E11	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	MRRF	Q96E11	WIPI2	Homo sapiens	Q9Y4P8-4	Validated Y2H	32296183
Intra	MRRF	Q96E11	WIPI2	Homo sapiens	Q9Y4P8-4	Y2H Array	32296183
Intra	MRRF	Q96E11	WIPI2	Homo sapiens	Q9Y4P8-4	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	ZNF408	Homo sapiens	Q9H9D4	Y2H Array	32296183
Intra	MRRF	Q96E11	ZNF408	Homo sapiens	Q9H9D4	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
Intra	MRRF	Q96E11	DBT	Homo sapiens	P11182	Anti Tag CoIP	28514442
Intra	MRRF	Q96E11	DBT	Homo sapiens	P11182	Anti Tag CoIP	33961781
Intra	MRRF	Q96E11	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	MRRF	Q96E11	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	SYP	Homo sapiens	P08247	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Kearns-Sayre Syndrome

Ophthalmoplegia	Mitochondrial Cytopathy
KSS	Ophthalmoplegia, Pigmentary Degeneration Of Retina, And Cardiomyopathy
Oculocraniosomatic Syndrome	Chronic Progressive External Ophthalmoplegia With Myopathy
Cpeo With Myopathy	Total Ophthalmoplegia
Ophthalmoplegia-Plus Syndrome	Ophthalmoplegia, Progressive External, With Ragged-Red Fibers
Cpeo With Ragged-Red Fibers	Oculomotor Paralysis
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication O	Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication Of Mitochondrial Dna
Proximal Tubulopathy, Diabetes Mellitus And Cerebellar Ataxia	Cpeo With Ragged Red Fibers
Ophthalmoplegia Plus Syndrome	Ophthalmoplegia, Progressive External, With Ragged Red Fibers
Kearns-Sayre Mitochondrial Cytopathy	Mitochondrial Myopathies

Uremic Neuropathy

Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis

SANDO	Mitochondrial Recessive Ataxia Syndrome
Spinocerebellar Ataxia With Epilepsy	Epilepsy, Progressive Myoclonic 5
Epm5	Miras
SCAE	Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions, Autosomal Recessive
Autosomal Recessive Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions	Progressive Myoclonic Epilepsy Type 5
Pme Type 5	Progressive Myoclonus Epilepsy Type 5
Sensory Ataxic Neuropathy-Dysarthria-Ophthalmoparesis Syndrome	Recessive Mitochondrial Ataxia Syndrome
Sensory Ataxic Neuropathy Dysarthria And Ophthalmoparesis	Mitochondrial Spinocerebellar Ataxia-Epilepsy Syndrome
Mscae	Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions Autosomal Recessive
Progressive Myoclonic Epilepsy With Sensory Ataxic Neuropathy	Epilepsy, Progressive Myoclonic, 5
Ataxia Neuropathy Spectrum

Chronic Progressive External Ophthalmoplegia

Progressive External Ophthalmoplegia	Cpeo
Peo	Ophthalmoplegia, Chronic Progressive External
Ophthalmoplegia, External, Progressive, Chronic	Graefe Disease
Peo - [Progressive External Ophthalmoplegia]	Ophthalmoplegia Plus Syndrome

Myoclonic Epilepsy Associated With Ragged-Red Fibers

Merrf Syndrome	MERRF
Fukuhara Syndrome	Myoclonic Epilepsy Associated With Ragged Red Fibers
Myoencephalopathy Ragged-Red Fiber Disease	Myoclonic Epilepsy - Ragged Red Fibers
Myoclonus Epilepsy And Ragged Red Fibers	Myoclonus With Epilepsy And With Ragged Red Fibers
Myoclonic Epilepsy With Ragged Red Fibers	Myoclonic Epilepsy With Ragged-Red Fibers
Fukuhara Disease	Myoclonus Epilepsy Associated With Ragged-Red Fibres
Myoclonus With Epilepsy With Ragged Red Fibers

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Mitochondrial Encephalomyopathy

Mitochondrial Encephalomyopathies

Encephalomyopathy, Mitochondrial

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08691	MRRF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MRRF	MGD	MGI:1915121
Rattus norvegicus	MRRF	RGD	RGD:1305897
Canis familiaris	MRRF	VGNC	VGNC:43428
Macaca mulatta	MRRF	VGNC	VGNC:74927
Bos taurus	MRRF	VGNC	VGNC:102827

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