MSC - musculin Gene

Homo sapiens

Also known as ABF1; MYOR; ABF-1; bHLHa22

Gene ID: 9242 | Gene type: protein coding

About MSC

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:71,841,560-71,844,412 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 13 paralogues. Broad expression in placenta (RPKM 12.2), gall bladder (RPKM 7.2) and 23 other tissues.

Summary

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

MSC Products(1)

mRNA	Protein	Name
NM_005098.4	NP_005089.2	musculin

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9584154	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSC Protein Structure

HLH

0
100
206 a.a.

Protein Preferred Names

Protein Names

musculin

activated B-cell factor 1, homolog of mouse musculin

Related Diseases

Diseases

Alias

Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3	ARCI3
Lamellar Ichthyosis 5	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 5, Formerly	Li5, Formerly
Li5	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive, Type 3

Rhabdomyosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12042	Pimasertib	Inhibitor	99.88%	Phase 2
HY-101215	Evobrutinib	Inhibitor	98.70%	Phase 2
HY-100501	M2698	Inhibitor	99.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1410	GsMTx4	Inhibitor	99.80%	Unkown
HY-P1410A	GsMTx4 TFA	Inhibitor	99.80%	Unkown
HY-123872	MSC1094308	Inhibitor	99.89%	Unkown
HY-101611	MSC2530818	Inhibitor	99.62%	Unkown
HY-P1410C	D-GsMTx4 TFA	Inhibitor	99.89%	Unkown
HY-147208	MSC-4106	Inhibitor	99.82%	Unkown
HY-132301	MSC-4381	Inhibitor	98.89%	Unkown
HY-148518	MSC-1186	Inhibitor	99.42%	Unkown
HY-N0898A	(-)-Catechin	Inhibitor	98.78%	Unkown
HY-P1410B	D-GsMTx4	Inhibitor	99.44%	Unkown
HY-110218	CW 008	Agonist	98.15%	Unkown
HY-N0008	Orcinol glucoside		99.57%	Unkown
HY-135827	Roginolisib	Inhibitor	99.89%	Unkown
HY-108628	SU16f	Inhibitor	99.09%	Unkown
HY-B1890	(±)-Catechin	Inhibitor	98.38%	Unkown
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-131032	KI-7	Agonist	99.16%	Unkown
HY-135827A	Roginolisib hemifumarate	Inhibitor	99.80%	Unkown
HY-108438	TCS 2210		/	Unkown
HY-110262	MSC 2032964A	Inhibitor	/	Unkown
HY-113568	CAY10581	Inhibitor	/	Unkown
HY-12042A	Pimasertib hydrochloride	Inhibitor	/	Unkown
HY-147511	PPARγ agonist 7	Agonist	/	Unkown
HY-160053	Gint4.T aptamer sodium	Chemical	/	Unkown
HY-168505	MSC-5046	Inhibitor	/	Unkown
HY-168506	MSC-1254	Inhibitor	/	Unkown
HY-N8917	(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Activator	/	Unkown
HY-RS08707	MSC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MSC	VGNC	VGNC:43436
Rattus norvegicus	MSC	RGD	RGD:1305496
Bos taurus	MSC	VGNC	VGNC:31691
Macaca mulatta	MSC	VGNC	VGNC:74930
Mus musculus	MSC	MGD	MGI:1333884
Others	MSC	NCBI

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