CHMP4C - charged multivesicular body protein 4C Gene

Homo sapiens

Also known as Shax3; SNF7-3; VPS32C

Gene ID: 92421 | Gene type: protein coding

About CHMP4C

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,732,448-81,759,515 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 19.0), small intestine (RPKM 14.8) and 19 other tissues.

Summary

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP4C Products(1)

mRNA	Protein	Name
NM_152284.4	NP_689497.1	charged multivesicular body protein 4c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14505570	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in abscission	IMP IMP: Inferred from mutant phenotype	22422861	GOA
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic cytokinesis checkpoint signaling	IMP IMP: Inferred from mutant phenotype	22422861	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	16554368	GOA
involved in negative regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	22422861	GOA
involved in nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	26040713	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	24482116	GOA
involved in regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	17984323	GOA
involved in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	22547407	GOA
involved in viral budding from plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding from plasma membrane	IMP IMP: Inferred from mutant phenotype	14505570	GOA
involved in viral budding via host ESCRT complex	IDA IDA: Inferred from direct assay	24878737	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Flemming body	IDA IDA: Inferred from direct assay	22422861	GOA
located in amphisome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	26040712	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	26040712	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in midbody	IDA IDA: Inferred from direct assay	22724069	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	16554368	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	26040713	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP4C Protein Structure

Snf7

0
100
200
233 a.a.

Protein Preferred Names

Protein Names

charged multivesicular body protein 4c

SNF7 homolog associated with Alix 3

CHMP4C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHMP4C	Q96CF2	PDCD6IP	Homo sapiens	Q8WUM4	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02645	CHMP4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CHMP4C	VGNC	VGNC:71143
Canis familiaris	CHMP4C	VGNC	VGNC:39224
Bos taurus	CHMP4C	VGNC	VGNC:27303
Felis catus	CHMP4C	VGNC	VGNC:60864
Rattus norvegicus	CHMP4C	RGD	RGD:1564543
Mus musculus	CHMP4C	MGD	MGI:1913621

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