PDCD6IP - programmed cell death 6 interacting protein Gene

Homo sapiens

Also known as AIP1; ALIX; HP95; DRIP4; MCPH29

Gene ID: 10015 | Gene type: protein coding

About PDCD6IP

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:33,798,630-33,869,703 (from NCBI)

This gene has 18 transcripts (splice variants) and 45 orthologues. Ubiquitous expression in colon (RPKM 28.2), esophagus (RPKM 23.0) and 25 other tissues.

Summary

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block Apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for Apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

PDCD6IP Products(3)

mRNA	Protein	Name
NM_001162429.3	NP_001155901.1	programmed cell death 6-interacting protein isoform 2
NM_001256192.2	NP_001243121.1	programmed cell death 6-interacting protein isoform 3
NM_013374.6	NP_037506.2	programmed cell death 6-interacting protein isoform 1

PDCD6IP Protein Structure

BRO1

ALIX_LYPXL_bnd

0
200
400
600
800
868 a.a.

Protein Preferred Names

Protein Names

programmed cell death 6-interacting protein

ALG-2 interacting protein 1

PDCD6IP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDCD6IP	Q8WUM4	CHMP4C	Homo sapiens	Q96CF2	SPR	18511562
Intra	PDCD6IP	Q8WUM4	CHMP4C	Homo sapiens	Q96CF2	X-Ray Diffraction	18511562
Intra	PDCD6IP	Q8WUM4	CD2AP	Homo sapiens	Q9Y5K6	Anti Tag CoIP	17853893
Intra	PDCD6IP	Q8WUM4	HCK	Homo sapiens	P08631	ITC	20670214
Intra	PDCD6IP	Q8WUM4	HCK	Homo sapiens	P08631	Y2H	22641034
Intra	PDCD6IP	Q8WUM4	HCK	Homo sapiens	P08631	NMR	22641034
Intra	PDCD6IP	Q8WUM4	PDCD6	Homo sapiens	O75340	Pull Down	18940611
Intra	PDCD6IP	Q8WUM4	PDCD6	Homo sapiens	O75340	Anti Tag CoIP	18256029
Intra	PDCD6IP	Q8WUM4	PDCD6	Homo sapiens	O75340	Pull Down	18256029
Cross	PDCD6IP	Q8WUM4	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Intra	PDCD6IP	Q8WUM4	FYN	Homo sapiens	P06241	Y2H	22641034
Cross	PDCD6IP	Q8WUM4	nef	Human immunodeficiency virus	Q90VU7	BiFC	25118280
Cross	PDCD6IP	Q8WUM4	nef	Human immunodeficiency virus	Q90VU7	Pull Down	25118280
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	IF	17853893
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	Y2H	17853893
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	25416956
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	Anti Tag CoIP	35271311
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	Y2H Array	31515488
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	Pull Down	18940611
Intra	PDCD6IP	Q8WUM4	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	25416956
Intra	PDCD6IP	Q8WUM4	CHMP4A	Homo sapiens	Q9BY43	SPR	18511562
Intra	PDCD6IP	Q8WUM4	CHMP4A	Homo sapiens	Q9BY43	X-Ray Diffraction	18511562
Intra	PDCD6IP	Q8WUM4	CHMP4B	Homo sapiens	Q9H444	SPR	18511562
Intra	PDCD6IP	Q8WUM4	CHMP4B	Homo sapiens	Q9H444	X-Ray Diffraction	18511562
Intra	PDCD6IP	Q8WUM4	CHMP4B	Homo sapiens	Q9H444	Anti Tag CoIP	21889351
Cross	PDCD6IP	Q8WUM4	Chmp4b	Mus musculus	Q9D8B3	Anti Bait CoIP	25686249
Cross	PDCD6IP	Q8WUM4	gag	Human immunodeficiency virus	P03347	SPR	17350572
Cross	PDCD6IP	Q8WUM4	gag	Equine infectious anemia virus	P69730	SPR	17350572
Cross	PDCD6IP	Q8WUM4	gag	Human immunodeficiency virus	O91079	FPS	37219487
Cross	PDCD6IP	Q8WUM4	gag	Human immunodeficiency virus	O91079	FPS	37100772
Cross	PDCD6IP	Q8WUM4	P29991-PRO_0000308465	Dengue virus type 2	P29991-PRO_0000308465	Y2H	21911577

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly 29, Primary, Autosomal Recessive

MCPH29

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10195	PDCD6IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDCD6IP	MGD	MGI:1333753
Felis catus	PDCD6IP	VGNC	VGNC:68746
Macaca mulatta	PDCD6IP	VGNC	VGNC:75795
Rattus norvegicus	PDCD6IP	RGD	RGD:68357
Bos taurus	PDCD6IP	VGNC	VGNC:32664
Canis familiaris	PDCD6IP	VGNC	VGNC:44341
Others	PDCD6IP	NCBI

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