STK17A - serine/threonine kinase 17a Gene

Homo sapiens

Also known as DRAK1

Gene ID: 9263 | Gene type: protein coding

About STK17A

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:43,583,108-43,627,379 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 25.5), bone marrow (RPKM 15.3) and 24 other tissues.

Summary

This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

STK17A Products(1)

mRNA	Protein	Name
NM_004760.3	NP_004751.2	serine/threonine-protein kinase 17A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9786912	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9786912	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9786912	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21489989	GOA
involved in positive regulation of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	9786912	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9786912	GOA
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21489989	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9786912	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK17A Protein Structure

Pkinase

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 17A

DAP kinase-related apoptosis-inducing protein kinase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148062	RSS0680		98.03%	Unkown
HY-163626A	STK17A/B-IN-1 hydrochloride	Inhibitor	/	Unkown
HY-163626	STK17A/B-IN-1	Inhibitor	/	Unkown
HY-RS13924	STK17A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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