1. Gene
  2. OLFM2 - olfactomedin 2 Gene

OLFM2 - olfactomedin 2 Gene

Homo sapiens

Also known as NOE2; OlfC; NOELIN2; NOELIN2_V1

Gene ID: 93145 | Gene type: protein coding

About OLFM2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:9,853,718-9,936,515 (from NCBI)

This gene has 5 transcripts (splice variants), 252 orthologues and 9 paralogues. Biased expression in brain (RPKM 38.1), skin (RPKM 32.4) and 13 other tissues.

Summary

Involved in positive regulation of smooth muscle cell differentiation. Acts upstream of or within protein secretion. Located in cytoplasm; extracellular region; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OLFM2 Products(3)

mRNA Protein Name
NM_001304347.2 NP_001291276.1 noelin-2 isoform 1
NM_001304348.2 NP_001291277.1 noelin-2 isoform 3
NM_058164.4 NP_477512.1 noelin-2 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25298399 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
25298399 GOA
acts upstream of or within protein secretion IDA
IDA: Inferred from direct assay
21228389 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25298399 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
21228389 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25298399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM2 Protein Structure

Noelin-1

Noelin-1: Neurogenesis glycoprotein (25 - 121)

OLF

OLF: Olfactomedin-like domain (198 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

noelin-2

neuronal olfactomedin related ER localized protein 2

OLFM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
OLFM2 O95897 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
OLFM2 O95897 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Open-Angle Glaucoma

Glaucoma Simplex

Pigmentary Glaucoma

Wide-Angle Glaucoma

Glaucoma, Open-Angle

Open Angle Glaucoma

Glaucoma Open-Angle

Chronic Simple Glaucoma

Coag - [Chronic Open-Angle Glaucoma]

Csg - [Chronic Simple Glaucoma]

Poag - [Primary Open-Angle Glaucoma]

Oag - [Open-Angle Glaucoma]

Chronic Glaucoma

Chronic Open Angle Glaucoma

Simple Glaucoma

Chronic Noncongestive Glaucoma

Ltg - [Low Tension Glaucoma]

Noncongestive Glaucoma

Nonobstructive Glaucoma

Normal Pressure Glaucoma

Primary Low Tension Glaucoma

Low-Tension Glaucoma

Residual Stage Low Tension Glaucoma

Open Cleft Glaucoma

Arteriosclerosis Obliterans
Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus OLFM2 RGD RGD:1309741
Bos taurus OLFM2 VGNC VGNC:32418
Macaca mulatta OLFM2 VGNC VGNC:75417
Mus musculus OLFM2 MGD MGI:3045350
Canis familiaris OLFM2 VGNC VGNC:44113
Felis catus OLFM2 VGNC VGNC:63959