OLFM2 - olfactomedin 2 Gene

Homo sapiens

Also known as NOE2; OlfC; NOELIN2; NOELIN2_V1

Gene ID: 93145 | Gene type: protein coding

About OLFM2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:9,853,718-9,936,515 (from NCBI)

This gene has 5 transcripts (splice variants), 252 orthologues and 9 paralogues. Biased expression in brain (RPKM 38.1), skin (RPKM 32.4) and 13 other tissues.

Summary

Involved in positive regulation of smooth muscle cell differentiation. Acts upstream of or within protein secretion. Located in cytoplasm; extracellular region; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OLFM2 Products(3)

mRNA	Protein	Name
NM_001304347.2	NP_001291276.1	noelin-2 isoform 1
NM_001304348.2	NP_001291277.1	noelin-2 isoform 3
NM_058164.4	NP_477512.1	noelin-2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25298399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	25298399	GOA
acts upstream of or within protein secretion	IDA IDA: Inferred from direct assay	21228389	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25298399	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	21228389	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25298399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM2 Protein Structure

Noelin-1

OLF

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

noelin-2

neuronal olfactomedin related ER localized protein 2

OLFM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OLFM2	O95897	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	OLFM2	O95897	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	OLFM2	O95897	NOTCH2NLC	Homo sapiens	P0DPK4	Validated Y2H	32296183
Intra	OLFM2	O95897	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	OLFM2	O95897	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Open-Angle Glaucoma

Glaucoma Simplex	Pigmentary Glaucoma
Wide-Angle Glaucoma	Glaucoma, Open-Angle
Open Angle Glaucoma	Glaucoma Open-Angle
Chronic Simple Glaucoma	Coag - [Chronic Open-Angle Glaucoma]
Csg - [Chronic Simple Glaucoma]	Poag - [Primary Open-Angle Glaucoma]
Oag - [Open-Angle Glaucoma]	Chronic Glaucoma
Chronic Open Angle Glaucoma	Simple Glaucoma
Chronic Noncongestive Glaucoma	Ltg - [Low Tension Glaucoma]
Noncongestive Glaucoma	Nonobstructive Glaucoma
Normal Pressure Glaucoma	Primary Low Tension Glaucoma
Low-Tension Glaucoma	Residual Stage Low Tension Glaucoma
Open Cleft Glaucoma

Arteriosclerosis Obliterans

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09771	OLFM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OLFM2	RGD	RGD:1309741
Bos taurus	OLFM2	VGNC	VGNC:32418
Macaca mulatta	OLFM2	VGNC	VGNC:75417
Mus musculus	OLFM2	MGD	MGI:3045350
Canis familiaris	OLFM2	VGNC	VGNC:44113
Felis catus	OLFM2	VGNC	VGNC:63959

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