FBXO44 - F-box protein 44 Gene

Homo sapiens

Also known as FBG3; FBX30; FBX6A; Fbx44; Fbxo6a

Gene ID: 93611 | Gene type: protein coding

About FBXO44

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,654,407-11,663,327 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 16.4), adrenal (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

FBXO44 Products(7)

mRNA	Protein	Name
NM_001014765.2	NP_001014765.1	F-box only protein 44 isoform 1
NM_001304790.2	NP_001291719.1	F-box only protein 44 isoform 2
NM_001304791.2	NP_001291720.1	F-box only protein 44 isoform 1
NM_001330355.2	NP_001317284.1	F-box only protein 44 isoform 3
NM_033182.7	NP_149438.2	F-box only protein 44 isoform 1
NM_183412.3	NP_904319.1	F-box only protein 44 isoform 2
NM_183413.3	NP_904320.1	F-box only protein 44 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18203720	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	25970626	GOA
acts upstream of or within proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	25970626	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	18203720	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO44 Protein Structure

F-box-like

FBA

0
100
200
255 a.a.

Protein Preferred Names

Protein Names

F-box only protein 44

F-box gene 3

FBXO44 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FBXO44	Q9H4M3	BORCS6	Homo sapiens	Q96GS4	Y2H Prey Pooling	25416956
Intra	FBXO44	Q9H4M3	SKP1	Homo sapiens	P63208	Y2H Prey Pooling	25416956
Intra	FBXO44	Q9H4M3	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	25416956
Intra	FBXO44	Q9H4M3	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04809	FBXO44 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FBXO44	VGNC	VGNC:107105
Mus musculus	FBXO44	MGD	MGI:1354744
Rattus norvegicus	FBXO44	RGD	RGD:1562463
Felis catus	FBXO44	VGNC	VGNC:107054

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