2. Gene
  3. FBXO44 - F-box protein 44 Gene

FBXO44 - F-box protein 44 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FBG3; FBX30; FBX6A; Fbx44; Fbxo6a

Gene ID: 93611 | Gene type: protein coding

About FBXO44

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,654,407-11,663,327 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 16.4), adrenal (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

FBXO44 Products(7)

mRNA Protein Name
NM_001014765.2 NP_001014765.1 F-box only protein 44 isoform 1
NM_001304790.2 NP_001291719.1 F-box only protein 44 isoform 2
NM_001304791.2 NP_001291720.1 F-box only protein 44 isoform 1
NM_001330355.2 NP_001317284.1 F-box only protein 44 isoform 3
NM_033182.7 NP_149438.2 F-box only protein 44 isoform 1
NM_183412.3 NP_904319.1 F-box only protein 44 isoform 2
NM_183413.3 NP_904320.1 F-box only protein 44 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18203720 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within proteasomal protein catabolic process IDA
IDA: Inferred from direct assay
25970626 GOA
acts upstream of or within proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25970626 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
18203720 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO44 Protein Structure

F-box-like

F-box-like: F-box-like (6 - 53)

FBA

FBA: F-box associated region (68 - 250)

  • 0
  • 100
  • 200
  • 255 a.a.
Protein Preferred Names Protein Names

F-box only protein 44

F-box gene 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04809 FBXO44 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FBXO44 VGNC VGNC:107105
Mus musculus FBXO44 MGD MGI:1354744
Rattus norvegicus FBXO44 RGD RGD:1562463
Felis catus FBXO44 VGNC VGNC:107054