TADA2B - transcriptional adaptor 2B Gene

Homo sapiens

Also known as ADA2B; ADA2(beta)

Gene ID: 93624 | Gene type: protein coding

About TADA2B

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,043,372-7,057,952 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 7.9) and 25 other tissues.

Summary

TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of Histone Acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

TADA2B Products(1)

mRNA	Protein	Name
NM_152293.3	NP_689506.2	transcriptional adapter 2-beta

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29232376	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SAGA-type complex	IDA IDA: Inferred from direct assay	18838386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TADA2B Protein Structure

Myb_DNA-binding

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

transcriptional adapter 2-beta

ADA2-beta

TADA2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TADA2B	Q86TJ2	AATF	Homo sapiens	Q9NY61	Y2H	29232376

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7	SCA7
Opca3	Opca Iii
Olivopontocerebellar Atrophy Iii	Opca With Retinal Degeneration
Opca With Macular Degeneration And External Ophthalmoplegia	Adca, Type Ii
Autosomal Dominant Cerebellar Ataxia Type 2	Olivopontocerebellar Atrophy 3
Autosomal Dominant Cerebellar Ataxia, Type Ii	Autosomal Dominant Cerebellar Ataxia Type Ii
Adca2	Adcaii
Ataxia With Pigmentary Retinopathy	Cerebellar Syndrome-Pigmentary Maculopathy Syndrome
Olivopontocerebellar Atrophy With Retinal Degeneration	Spinocerebellar Ataxia-7
Ataxia, Spinocerebellar, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14155	TADA2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TADA2B	VGNC	VGNC:107202
Mus musculus	TADA2B	MGD	MGI:3035274
Felis catus	TADA2B	VGNC	VGNC:65923
Rattus norvegicus	TADA2B	RGD	RGD:1561605
Canis familiaris	TADA2B	VGNC	VGNC:47071

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