2. Gene
  3. TJAP1 - tight junction associated protein 1 Gene

TJAP1 - tight junction associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PILT; TJP4

Gene ID: 93643 | Gene type: protein coding

About TJAP1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,477,570-43,506,554 (from NCBI)

This gene has 15 transcripts (splice variants) and 85 orthologues. Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]

TJAP1 Products(24)

mRNA Protein Name
NM_001146016.2 NP_001139488.1 tight junction-associated protein 1 isoform a
NM_001146017.2 NP_001139489.1 tight junction-associated protein 1 isoform a
NM_001146018.2 NP_001139490.1 tight junction-associated protein 1 isoform b
NM_001146019.2 NP_001139491.1 tight junction-associated protein 1 isoform b
NM_001146020.2 NP_001139492.1 tight junction-associated protein 1 isoform b
NM_001350561.2 NP_001337490.1 tight junction-associated protein 1 isoform a
NM_001350562.2 NP_001337491.1 tight junction-associated protein 1 isoform a
NM_001350563.2 NP_001337492.1 tight junction-associated protein 1 isoform a
NM_001350564.2 NP_001337493.1 tight junction-associated protein 1 isoform a
NM_001350565.2 NP_001337494.1 tight junction-associated protein 1 isoform a
NM_001350566.2 NP_001337495.1 tight junction-associated protein 1 isoform a
NM_001350567.2 NP_001337496.1 tight junction-associated protein 1 isoform a
NM_001350568.2 NP_001337497.1 tight junction-associated protein 1 isoform a
NM_001350569.2 NP_001337498.1 tight junction-associated protein 1 isoform b
NM_001350570.2 NP_001337499.1 tight junction-associated protein 1 isoform b
NM_001394538.1 NP_001381467.1 tight junction-associated protein 1 isoform c
NM_001394539.1 NP_001381468.1 tight junction-associated protein 1 isoform c
NM_001394540.1 NP_001381469.1 tight junction-associated protein 1 isoform d
NM_001394541.1 NP_001381470.1 tight junction-associated protein 1 isoform d
NM_001394542.1 NP_001381471.1 tight junction-associated protein 1 isoform d
NM_001394543.1 NP_001381472.1 tight junction-associated protein 1 isoform d
NM_001394544.1 NP_001381473.1 tight junction-associated protein 1 isoform d
NM_001394545.1 NP_001381474.1 tight junction-associated protein 1 isoform d
NM_080604.3 NP_542171.2 tight junction-associated protein 1 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TJAP1 Protein Structure

Pilt

Pilt: Protein incorporated later into Tight Junctions (266 - 556)

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  • 557 a.a.
Protein Preferred Names Protein Names

tight junction-associated protein 1

protein incorporated later into tight junctions

Related Diseases

Diseases Alias
Siberian Tick Typhus

North Asian Tick Typhus

Manchurian Typhus

North Asian Tick Fever

Rickettsia Sibirica Spotted Fever

Spotted Fever Group Rickettsiosis
Fallopian Tube Disease

Fallopian Tube Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14552 TJAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TJAP1 VGNC VGNC:47385
Bos taurus TJAP1 VGNC VGNC:35880
Macaca mulatta TJAP1 VGNC VGNC:78407
Mus musculus TJAP1 MGD MGI:1921344
Felis catus TJAP1 VGNC VGNC:66198
Rattus norvegicus TJAP1 RGD RGD:1308708