TRIM54 - tripartite motif containing 54 Gene

Homo sapiens

Also known as MURF; RNF30; muRF3; MURF-3

Gene ID: 57159 | Gene type: protein coding

About TRIM54

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,282,429-27,307,435 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 80 paralogues. Biased expression in heart (RPKM 35.4), testis (RPKM 5.2) and 2 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TRIM54 Products(2)

mRNA	Protein	Name
NM_032546.4	NP_115935.3	tripartite motif-containing protein 54 isoform 1
NM_187841.3	NP_912730.2	tripartite motif-containing protein 54 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM54 Protein Structure

zf-C3HC4_2

zf-B_box

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 54

muscle-specific RING finger protein 3

Related Diseases

Diseases

Alias

Hyaline Body Myopathy

Myosin Storage Myopathy	Autosomal Dominant Hyaline Body Myopathy
Myopathy, Myosin Storage

Myopathy, Myofibrillar, 9, With Early Respiratory Failure

Hereditary Myopathy With Early Respiratory Failure	Hmerf
Myopathy, Proximal, With Early Respiratory Muscle Involvement	Edstrom Myopathy
Mfm-Titinopathy	MFM9
Mprm	Hereditary Inclusion Body Myopathy With Early Respiratory Failure
Hibm-Erf	Myofibrillar Myopathy-Titinopathy
Myofibrillar Myopathy With Early Respiratory Failure	Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant
Myofibrillar Myopathy 9	Myofibrillar Myopathy 9 With Early Respiratory Failure
Autosomal Dominant Distal Myopathy With Early Respiratory Failure	Proximal Myopathy With Early Respiratory Muscle Involvement
Hereditary Proximal Myopathy With Early Respiratory Failure	Admerf
Edström Myopathy	Hmerf-Erf

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15055	TRIM54 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM54	VGNC	VGNC:36340
Felis catus	TRIM54	VGNC	VGNC:66544
Macaca mulatta	TRIM54	VGNC	VGNC:79003
Rattus norvegicus	TRIM54	RGD	RGD:1306453
Canis familiaris	TRIM54	VGNC	VGNC:47826
Mus musculus	TRIM54	MGD	MGI:1889623
Others	TRIM54	NCBI

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