RAB9A - RAB9A, member RAS oncogene family Gene

Homo sapiens

Also known as RAB9

Gene ID: 9367 | Gene type: protein coding

About RAB9A

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:13,689,128-13,710,504 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues and 68 paralogues. Ubiquitous expression in adrenal (RPKM 21.5), bone marrow (RPKM 11.2) and 25 other tissues.

Summary

Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

RAB9A Products(2)

mRNA	Protein	Name
NM_001195328.2	NP_001182257.1	ras-related protein Rab-9A
NM_004251.5	NP_004242.1	ras-related protein Rab-9A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	15263003	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	15263003	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	15263003	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15471887	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation by host of symbiont catalytic activity	IMP IMP: Inferred from mutant phenotype	18787122	GOA
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	19966785	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	18787122	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in late endosome	IDA IDA: Inferred from direct assay	15078902	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15078902	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB9A Protein Structure

Ras

0
100
201 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-9A

RAB9, member RAS oncogene family

RAB9A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB9A	P51151	NISCH	Homo sapiens	Q9Y2I1	IF	23386062
Intra	RAB9A	P51151	NISCH	Homo sapiens	Q9Y2I1	BioID	29568061
Intra	RAB9A	P51151	PLEKHM2	Homo sapiens	Q8IWE5	Pull Down	18787122

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB9A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82055	Rab9 Antibody (YA1800)	WB, IHC-P	Human, Mouse

Related Diseases

Diseases

Alias

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Simpson-Golabi-Behmel Syndrome, Type 2

Simpson-Golabi-Behmel Syndrome Type 2	SGBS2
Simpson-Golabi-Behmel Syndrome 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11580	RAB9A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB9A	RGD	RGD:619740
Mus musculus	RAB9A	MGD	MGI:1890695
Canis familiaris	RAB9A	VGNC	VGNC:45297
Bos taurus	RAB9A	VGNC	VGNC:33664
Macaca mulatta	RAB9A	VGNC	VGNC:81551
Felis catus	RAB9A	VGNC	VGNC:97596

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