Hrg - histidine-rich glycoprotein Gene

Mus musculus

Also known as Hprg; Hrgp; D16jh2; D18020

Gene ID: 94175 | Gene type: protein coding

About Hrg

Summary

Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; positive regulation of blood vessel remodeling; and positive regulation of immune response to tumor cell. Acts upstream of or within several processes, including heme export; negative regulation of fibrinolysis; and regulation of transcription from RNA polymerase II promoter in response to iron. Located in endolysosome and phagolysosome membrane. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Hrg Products(1)

mRNA	Protein	Name
NM_053176.2	NP_444406.2	histidine-rich glycoprotein precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15748999	MGI
enables serine-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	15869579	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	18797515	MGI
involved in defense response to fungus	IMP IMP: Inferred from mutant phenotype	18797515	MGI
acts upstream of fibrinolysis	IMP IMP: Inferred from mutant phenotype	15869579	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	22348394	MGI
involved in negative regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	22348394	MGI
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	22348394	MGI
acts upstream of or within negative regulation of fibrinolysis	IMP IMP: Inferred from mutant phenotype	15869579	MGI
involved in positive regulation of blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	22348394	MGI
involved in positive regulation of immune response to tumor cell	IMP IMP: Inferred from mutant phenotype	22348394	MGI
involved in regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	15869579	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22348394	MGI
involved in regulation of platelet activation	IMP IMP: Inferred from mutant phenotype	15869579	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histidine-rich glycoprotein

histidine-proline-rich glycoprotein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06358	HRG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hrg	NCBI	NCBI:3273
Canis familiaris	Hrg	NCBI	NCBI:100683193
Rattus norvegicus	Hrg	NCBI	NCBI:171016

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