THEMIS2 - thymocyte selection associated family member 2 Gene

Homo sapiens

Also known as ICB1; ICB-1; C1orf38

Gene ID: 9473 | Gene type: protein coding

About THEMIS2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,872,544-27,886,675 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 58.1), spleen (RPKM 43.6) and 17 other tissues.

Summary

Predicted to be involved in T cell receptor signaling pathway and regulation of B cell activation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

THEMIS2 Products(5)

mRNA	Protein	Name
NM_001039477.3	NP_001034566.1	protein THEMIS2 isoform 2
NM_001105556.3	NP_001099026.1	protein THEMIS2 isoform 3
NM_001286113.2	NP_001273042.1	protein THEMIS2 isoform 4
NM_001286115.2	NP_001273044.1	protein THEMIS2 isoform 5
NM_004848.4	NP_004839.2	protein THEMIS2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THEMIS2 Protein Structure

CABIT

0
100
200
300
400
500
600
643 a.a.

Protein Preferred Names

Protein Names

protein THEMIS2

basement membrane-induced

Related Diseases

Diseases

Alias

Endometrial Adenocarcinoma

Endometrial Endometrioid Adenocarcinoma	Endometrial Adenoacanthoma
Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation	Adenocarcinoma Of Endometrium
Adenocarcinoma Of The Endometrium	Adenocarcinoma Of Uterus
Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation	Endometrioid Adenoma Or Carcinoma
Endometrioid Adenomas And Carcinomas	Endometrioid Carcinoma Of Endometrium
Endometrium Adenocarcinoma

Xia-Gibbs Syndrome

Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome	XIGIS
Mrd25	Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome
Mental Retardation, Autosomal Dominant 25, Formerly	Mrd25, Formerly
Autosomal Dominant Mental Retardation 25	Autosomal Dominant Intellectual Disability 25
Xgs

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14489	THEMIS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	THEMIS2	RGD	RGD:1561016
Bos taurus	THEMIS2	VGNC	VGNC:35836
Mus musculus	THEMIS2	MGD	MGI:2446213
Macaca mulatta	THEMIS2	VGNC	VGNC:78397
Canis familiaris	THEMIS2	VGNC	VGNC:47344
Felis catus	THEMIS2	VGNC	VGNC:66162

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