PAGE4 - PAGE family member 4 Gene

Homo sapiens

Also known as JM27; JM-27; CT16.7; GAGE-9; GAGEC1; PAGE-1; PAGE-4

Gene ID: 9506 | Gene type: protein coding

About PAGE4

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,829,260-49,834,264 (from NCBI)

This gene has 4 transcripts (splice variants), 47 orthologues and 22 paralogues. Restricted expression toward placenta (RPKM 272.2).

Summary

This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate Cancer. It is also expressed in Other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular Cancer and uterine Cancer. The protein encoded by this gene shares sequence similarity with Other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

PAGE4 Products(2)

mRNA	Protein	Name
NM_001318877.1	NP_001305806.1	P antigen family member 4
NM_007003.4	NP_008934.1	P antigen family member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	21357425	GOA
enables nucleic acid binding	EXP EXP: Inferred from Experiment	21357425	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24263171	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	24263171	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	24559171	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	30658679	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	25374899	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21357425	GOA
involved in negative regulation of reactive oxygen species biosynthetic process	IDA IDA: Inferred from direct assay	25374899	GOA
involved in response to starvation	IDA IDA: Inferred from direct assay	25374899	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12489849	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25374899	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24559171	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAGE4 Protein Structure

GAGE

0
102 a.a.

Protein Preferred Names

Protein Names

P antigen family member 4

P antigen family, member 4 (prostate associated)

PAGE4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PAGE4	O60829	JUN	Homo sapiens	P05412	NMR	26242913

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Progesterone-Receptor Negative Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09976	PAGE4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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