2. Gene
  3. EI24 - EI24 autophagy associated transmembrane protein Gene

EI24 - EI24 autophagy associated transmembrane protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EPG4; PIG8; TP53I8

Gene ID: 9538 | Gene type: protein coding

About EI24

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,569,477-125,584,684 (from NCBI)

This gene has 14 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in liver (RPKM 39.6), colon (RPKM 30.4) and 25 other tissues.

Summary

This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated Apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the Caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

EI24 Products(3)

mRNA Protein Name
NM_001290135.2 NP_001277064.1 etoposide-induced protein 2.4 homolog isoform 3
NM_001330419.2 NP_001317348.1 etoposide-induced protein 2.4 homolog isoform 4
NM_004879.5 NP_004870.3 etoposide-induced protein 2.4 homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables importin-alpha family protein binding IPI
IPI: Inferred from physical interaction
24821838 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of cell growth IDA
IDA: Inferred from direct assay
10594026 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EI24 Protein Structure

EI24

EI24: Etoposide-induced protein 2.4 (EI24) (64 - 272)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

etoposide-induced protein 2.4 homolog

ectopic P-granules autophagy protein 4 homolog

EI24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EI24 O14681 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
EI24 O14681 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
EI24 O14681 PGRMC2 Homo sapiens O15173
Validated Y2H
32296183
Intra
EI24 O14681 TMED8 Homo sapiens Q6PL24
Validated Y2H
32296183
Intra
EI24 O14681 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra
EI24 O14681 BNIP2 Homo sapiens Q12982
Validated Y2H
32296183
Intra
EI24 O14681 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
EI24 O14681 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
EI24 O14681 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04233 EI24 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EI24 VGNC VGNC:28376
Macaca mulatta EI24 VGNC VGNC:72038
Canis familiaris EI24 VGNC VGNC:40251
Rattus norvegicus EI24 RGD RGD:1309868
Mus musculus EI24 MGD MGI:108090