2. Gene
  3. EI24 - EI24 autophagy associated transmembrane protein Gene

EI24 - EI24 autophagy associated transmembrane protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EPG4; PIG8; TP53I8

Gene ID: 9538 | Gene type: protein coding

About EI24

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,569,477-125,584,684 (from NCBI)

This gene has 14 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in liver (RPKM 39.6), colon (RPKM 30.4) and 25 other tissues.

Summary

This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated Apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the Caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

EI24 Products(3)

mRNA Protein Name
NM_001290135.2 NP_001277064.1 etoposide-induced protein 2.4 homolog isoform 3
NM_001330419.2 NP_001317348.1 etoposide-induced protein 2.4 homolog isoform 4
NM_004879.5 NP_004870.3 etoposide-induced protein 2.4 homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables importin-alpha family protein binding IPI
IPI: Inferred from physical interaction
24821838 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of cell growth IDA
IDA: Inferred from direct assay
10594026 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EI24 Protein Structure

EI24

EI24: Etoposide-induced protein 2.4 (EI24) (64 - 272)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

etoposide-induced protein 2.4 homolog

ectopic P-granules autophagy protein 4 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04233 EI24 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EI24 VGNC VGNC:28376
Macaca mulatta EI24 VGNC VGNC:72038
Canis familiaris EI24 VGNC VGNC:40251
Rattus norvegicus EI24 RGD RGD:1309868
Mus musculus EI24 MGD MGI:108090