BNIP2 - BCL2 interacting protein 2 Gene

Homo sapiens

Also known as NIP2; BNIP-2

Gene ID: 663 | Gene type: protein coding

About BNIP2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:59,659,146-59,689,320 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 22.4), fat (RPKM 13.5) and 24 other tissues.

Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

BNIP2 Products(8)

mRNA	Protein	Name
NM_001320674.2	NP_001307603.2	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 1
NM_001320675.4	NP_001307604.2	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2
NM_001368057.1	NP_001354986.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 4
NM_001368058.1	NP_001354987.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 5
NM_001368059.1	NP_001354988.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 6
NM_001368060.1	NP_001354989.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 7
NM_001368061.1	NP_001354990.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 8
NM_004330.4	NP_004321.3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7954800	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7954800	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	7954800	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	7954800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIP2 Protein Structure

BNIP2

CRAL_TRIO_2

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

BCL2/adenovirus E1B 19kDa interacting protein 2

BNIP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BNIP2	Q12982	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	32296183
Intra	BNIP2	Q12982	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	BNIP2	Q12982	b2r9h7_human	Homo sapiens	B2R9H7	Y2H Array	25416956
Intra	BNIP2	Q12982	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	BNIP2	Q12982	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	BNIP2	Q12982	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	BNIP2	Q12982	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	BNIP2	Q12982	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	BNIP2	Q12982	GRAMD2A	Homo sapiens	Q8IUY3	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	GRAMD2A	Homo sapiens	Q8IUY3	Validated Y2H	32296183
Intra	BNIP2	Q12982	GRAMD2A	Homo sapiens	Q8IUY3	Y2H Array	32296183
Intra	BNIP2	Q12982	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	BNIP2	Q12982	BNIP5	Homo sapiens	P0C671	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	BNIP5	Homo sapiens	P0C671	Y2H Array	32296183
Intra	BNIP2	Q12982	RASGRP4	Homo sapiens	Q8TDF6-2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	RASGRP4	Homo sapiens	Q8TDF6-2	Validated Y2H	32296183
Intra	BNIP2	Q12982	RASGRP4	Homo sapiens	Q8TDF6-2	Y2H Array	32296183
Intra	BNIP2	Q12982	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	BNIP2	Q12982	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	DGAT2L6	Homo sapiens	Q6ZPD8	Validated Y2H	32296183
Intra	BNIP2	Q12982	DESI2	Homo sapiens	Q9BSY9	Validated Y2H	32296183
Intra	BNIP2	Q12982	DESI2	Homo sapiens	Q9BSY9	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	DESI2	Homo sapiens	Q9BSY9	Y2H Array	32296183
Intra	BNIP2	Q12982	FAHD1	Homo sapiens	Q6P587-2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	FAHD1	Homo sapiens	Q6P587-2	Y2H Array	32296183
Intra	BNIP2	Q12982	FAHD1	Homo sapiens	Q6P587-2	Validated Y2H	32296183
Intra	BNIP2	Q12982	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	BNIP2	Q12982	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	BNIP2	Q12982	SIN3A	Homo sapiens	H3BQL7	Y2H Array	32296183
Intra	BNIP2	Q12982	SIN3A	Homo sapiens	H3BQL7	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	SLC35E3	Homo sapiens	Q7Z769	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	SLC35E3	Homo sapiens	Q7Z769	Validated Y2H	32296183
Intra	BNIP2	Q12982	SLC35E3	Homo sapiens	Q7Z769	Y2H Array	32296183
Intra	BNIP2	Q12982	FRK	Homo sapiens	P42685	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	FRK	Homo sapiens	P42685	Y2H Array	25416956
Intra	BNIP2	Q12982	FRK	Homo sapiens	P42685	Y2H Array	32296183
Intra	BNIP2	Q12982	FRK	Homo sapiens	P42685	Y2H Array	31515488
Intra	BNIP2	Q12982	MYO5B	Homo sapiens	Q9ULV0-2	Validated Y2H	32296183
Intra	BNIP2	Q12982	MYO5B	Homo sapiens	Q9ULV0-2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	MYO5B	Homo sapiens	Q9ULV0-2	Y2H Array	32296183
Intra	BNIP2	Q12982	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	BNIP2	Q12982	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	BNIP2	Q12982	CHODL	Homo sapiens	Q9H9P2	Y2H Array	32296183
Intra	BNIP2	Q12982	CHODL	Homo sapiens	Q9H9P2	Validated Y2H	32296183
Intra	BNIP2	Q12982	CHODL	Homo sapiens	Q9H9P2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	APOBEC3B	Homo sapiens	Q9UH17-2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	APOBEC3B	Homo sapiens	Q9UH17-2	Y2H Array	32296183
Intra	BNIP2	Q12982	APOBEC3B	Homo sapiens	Q9UH17-2	Validated Y2H	32296183
Intra	BNIP2	Q12982	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	BNIP2	Q12982	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	BNIP2	Q12982	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	BNIP2	Q12982	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	BNIP2	Q12982	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	BNIP2	Q12982	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	EI24	Homo sapiens	O14681	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	EI24	Homo sapiens	O14681	Y2H Array	32296183
Intra	BNIP2	Q12982	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	BNIP2	Q12982	AGPAT3	Homo sapiens	Q9NRZ7	Validated Y2H	32296183
Intra	BNIP2	Q12982	AGPAT3	Homo sapiens	Q9NRZ7	Y2H Array	32296183
Intra	BNIP2	Q12982	AGPAT3	Homo sapiens	Q9NRZ7	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	SLC39A9	Homo sapiens	Q9NUM3	Y2H Array	32296183
Intra	BNIP2	Q12982	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	BNIP2	Q12982	SLC39A9	Homo sapiens	Q9NUM3	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	BNIP2	Q12982	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	BNIP2	Q12982	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	BNIP2	Q12982	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	BNIP2	Q12982	MYO5B	Homo sapiens	Q9ULV0	Validated Y2H	25416956
Intra	BNIP2	Q12982	MYO5B	Homo sapiens	Q9ULV0	Y2H Array	25416956
Intra	BNIP2	Q12982	MYO5B	Homo sapiens	Q9ULV0	Y2H Prey Pooling	25416956
Intra	BNIP2	Q12982	ERLIN1	Homo sapiens	O75477	Y2H Array	32296183
Intra	BNIP2	Q12982	ERLIN1	Homo sapiens	O75477	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	BNIP2	Q12982	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	BNIP2	Q12982	KCNK5	Homo sapiens	O95279	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	KCNK5	Homo sapiens	O95279	Y2H Array	32296183
Intra	BNIP2	Q12982	SFT2D2	Homo sapiens	O95562	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	SFT2D2	Homo sapiens	O95562	Y2H Array	32296183
Intra	BNIP2	Q12982	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	BNIP2	Q12982	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	BNIP2	Q12982	SYT1	Homo sapiens	P21579	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	SYT1	Homo sapiens	P21579	Y2H Array	32296183
Intra	BNIP2	Q12982	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	BNIP2	Q12982	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	BNIP2	Q12982	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	BNIP2	Q12982	ABHD4	Homo sapiens	Q8TB40	Y2H Array	32296183
Intra	BNIP2	Q12982	ABHD4	Homo sapiens	Q8TB40	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	ABHD4	Homo sapiens	Q8TB40	Validated Y2H	32296183
Intra	BNIP2	Q12982	KLC1	Homo sapiens	Q07866	Y2H Prey Pooling	25416956
Intra	BNIP2	Q12982	KLC1	Homo sapiens	Q07866	Y2H Array	25416956
Intra	BNIP2	Q12982	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	BNIP2	Q12982	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	DHRS1	Homo sapiens	Q96LJ7	Y2H Array	32296183
Intra	BNIP2	Q12982	DHRS1	Homo sapiens	Q96LJ7	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	DHRS1	Homo sapiens	Q96LJ7	Validated Y2H	32296183
Intra	BNIP2	Q12982	BNIP3	Homo sapiens	Q12983	Y2H Array	32296183
Intra	BNIP2	Q12982	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	BNIP2	Q12982	SYT2	Homo sapiens	Q8N9I0	Validated Y2H	32296183
Intra	BNIP2	Q12982	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183
Intra	BNIP2	Q12982	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	BNIP2	Q12982	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183
Intra	BNIP2	Q12982	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Intra	BNIP2	Q12982	PLEKHO1	Homo sapiens	Q53GL0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebellar Ataxia, Cayman Type

Cayman Type Cerebellar Ataxia	Ataxia, Cerebellar, Cayman Type
ATCAY	Cayman Cerebellar Ataxia
Cayman Ataxia

Nephronophthisis 3

NPHP3	Nph3
Adolescent Nephronophthisis	Nephronophthisis, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01563	BNIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BNIP2	MGD	MGI:109327
Macaca mulatta	BNIP2	VGNC	VGNC:70272
Bos taurus	BNIP2	VGNC	VGNC:26532
Rattus norvegicus	BNIP2	RGD	RGD:1308944
Felis catus	BNIP2	VGNC	VGNC:60144
Canis familiaris	BNIP2	VGNC	VGNC:58293

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