TP53I3 - tumor protein p53 inducible protein 3 Gene

Homo sapiens

Also known as PIG3

Gene ID: 9540 | Gene type: protein coding

About TP53I3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,077,433-24,084,834 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 17 paralogues. Broad expression in esophagus (RPKM 29.3), small intestine (RPKM 17.8) and 24 other tissues.

Summary

The protein encoded by this gene is similar to oxidoreductases, which are Enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to Cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

TP53I3 Products(3)

mRNA	Protein	Name
NM_001206802.2	NP_001193731.1	quinone oxidoreductase PIG3 isoform 2
NM_004881.5	NP_004872.2	quinone oxidoreductase PIG3 isoform 1
NM_147184.4	NP_671713.1	quinone oxidoreductase PIG3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADPH binding	IDA IDA: Inferred from direct assay	19349281	GOA
enables NADPH:quinone reductase activity	IDA IDA: Inferred from direct assay	19349281	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19349281	GOA
enables quinone binding	IDA IDA: Inferred from direct assay	19349281	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADP metabolic process	IDA IDA: Inferred from direct assay	19349281	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53I3 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

quinone oxidoreductase PIG3

NADPH:quinone reductase PIG3

Recombinant TP53I3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74632	PIG3 Protein, Human (His)	Q53FA7 (M1-Q332)	≥95%

Related Diseases

Diseases

Alias

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14919	TP53I3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TP53I3	VGNC	VGNC:47724
Rattus norvegicus	TP53I3	RGD	RGD:41235940
Macaca mulatta	TP53I3	VGNC	VGNC:79194
Bos taurus	TP53I3	VGNC	VGNC:36235
Felis catus	TP53I3	VGNC	VGNC:66464
Others	TP53I3	NCBI

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