CHD1L - chromodomain helicase DNA binding protein 1 like Gene

Homo sapiens

Also known as ALC1; CHDL

Gene ID: 9557 | Gene type: protein coding

About CHD1L

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:147,172,747-147,295,762 (from NCBI)

This gene has 33 transcripts (splice variants), 196 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]

CHD1L Products(21)

mRNA	Protein	Name
NM_001256336.3	NP_001243265.1	chromodomain-helicase-DNA-binding protein 1-like isoform 2
NM_001256337.3	NP_001243266.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001256338.3	NP_001243267.1	chromodomain-helicase-DNA-binding protein 1-like isoform 5
NM_001348451.2	NP_001335380.1	chromodomain-helicase-DNA-binding protein 1-like isoform 6
NM_001348452.2	NP_001335381.1	chromodomain-helicase-DNA-binding protein 1-like isoform 6
NM_001348453.2	NP_001335382.1	chromodomain-helicase-DNA-binding protein 1-like isoform 3
NM_001348454.2	NP_001335383.1	chromodomain-helicase-DNA-binding protein 1-like isoform 8
NM_001348455.2	NP_001335384.1	chromodomain-helicase-DNA-binding protein 1-like isoform 9
NM_001348456.2	NP_001335385.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348457.2	NP_001335386.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348458.2	NP_001335387.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348459.2	NP_001335388.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348460.2	NP_001335389.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348461.2	NP_001335390.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348462.2	NP_001335391.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348463.2	NP_001335392.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348464.2	NP_001335393.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348465.2	NP_001335394.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348466.2	NP_001335395.1	chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_004284.6	NP_004275.4	chromodomain-helicase-DNA-binding protein 1-like isoform 1
NM_024568.4	NP_078844.2	chromodomain-helicase-DNA-binding protein 1-like isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	19661379	GOA
enables ATP-dependent chromatin remodeler activity	IDA IDA: Inferred from direct assay	29220652	GOA
enables histone reader activity	IDA IDA: Inferred from direct assay	34874266	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	33357431	GOA
enables nucleotide binding	IDA IDA: Inferred from direct assay	19661379	GOA
enables poly-ADP-D-ribose modification-dependent protein binding	IDA IDA: Inferred from direct assay	29220652	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19661379	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	19661379	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	34486521	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	19661379	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19661379	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	34486521	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	29220652	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHD1L Protein Structure

SNF2_N

Helicase_C

0
200
400
600
800
897 a.a.

Protein Preferred Names

Protein Names

chromodomain-helicase-DNA-binding protein 1-like

amplified in liver cancer 1

Recombinant CHD1L Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71588	CHD1L Protein, Human (His-SUMO)	Q86WJ1 (S704-P897)	≥95%

CHD1L Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82491	CHD1L Antibody (YA2236)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse

Related Diseases

Diseases

Alias

Postcholecystectomy Syndrome

Post Cholecystectomy Syndrome

Thrombophlebitis Migrans

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144256	CHD1Li 6.11	Inhibitor	99.54%	Unkown
HY-RS02606	CHD1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CHD1L	VGNC	VGNC:71027
Rattus norvegicus	CHD1L	RGD	RGD:1311935
Canis familiaris	CHD1L	VGNC	VGNC:49732
Felis catus	CHD1L	VGNC	VGNC:60843
Mus musculus	CHD1L	MGD	MGI:1915308
Bos taurus	CHD1L	VGNC	VGNC:27277
Others	CHD1L	NCBI

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