2. Gene
  3. MINPP1 - multiple inositol-polyphosphate phosphatase 1 Gene

MINPP1 - multiple inositol-polyphosphate phosphatase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MIPP; PCH16; HIPER1; MINPP2

Gene ID: 9562 | Gene type: protein coding

About MINPP1

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:87,504,893-87,553,461 (from NCBI)

This gene has 4 transcripts (splice variants), 301 orthologues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.4), adrenal (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes multiple inositol polyphosphate phosphatase; an Enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only Enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This Enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

MINPP1 Products(3)

mRNA Protein Name
NM_001178117.2 NP_001171588.1 multiple inositol polyphosphate phosphatase 1 isoform 2 precursor
NM_001178118.2 NP_001171589.1 multiple inositol polyphosphate phosphatase 1 isoform 3
NM_004897.5 NP_004888.2 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables bisphosphoglycerate 3-phosphatase activity IDA
IDA: Inferred from direct assay
18413611 GOA
enables inositol bisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol pentakisphosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
33257696 GOA
enables inositol trisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
NOT enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-hexakisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-hexakisphosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
33257696 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of intracellular monoatomic cation homeostasis IMP
IMP: Inferred from mutant phenotype
33257696 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in extracellular space IMP
IMP: Inferred from mutant phenotype
33257696 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MINPP1 Protein Structure

His_Phos_2

His_Phos_2: Histidine phosphatase superfamily (branch 2) (82 - 439)

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  • 487 a.a.
Protein Preferred Names Protein Names

multiple inositol polyphosphate phosphatase 1

2,3-BPG phosphatase

Recombinant MINPP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70937 MINPP1 Protein, Human (HEK293, His) Q9UNW1 (S31-L487) ≥95%
HY-P71854 MINPP1 Protein, Human (P.pastoris, His) Q9UNW1 (31S-487L) ≥95%

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 16

PCH16

Pontocerebellar Hypoplasia Type 16

Pontocerebellar Hypoplasia 16

Doid:0112333
Thyroid Cancer, Nonmedullary, 2

Thyroid Carcinoma, Follicular

Follicular Thyroid Carcinoma

NMTC2

Thyroid Cancer, Follicular

Thyroid Carcinoma, Follicular, Somatic

Ftc

Thyroid Cancer, Non-Medullary, 2

Thyroid Follicular Carcinoma

Follicular Thyroid Cancer

Cancer, Thyroid, Nonmedullary, Type 2

Thyroid Gland Adenocarcinoma

Follicular Carcinoma Of Unspecified Site

Moderately Differentiated Follicular Carcinoma Of Thyroid Gland

Pure Follicle Carcinoma Of Thyroid Gland

Pure Follicle Follicular Carcinoma Of Unspecified Site

Pure Follicular Carcinoma Of Thyroid Gland

Trabecular Follicular Carcinoma Of Thyroid Gland

Trabecular Follicular Carcinoma Of Unspecified Site

Well Differentiated Follicular Carcinoma Of Unspecified Site

Well Differentiated Follicular Carcinoma Of Thyroid Gland
Pontocerebellar Hypoplasia, Type 7

Pontocerebellar Hypoplasia Type 7

PCH7

Pontocerebellar Hypoplasia-46,Xy Disorder Of Sex Development Syndrome

Pontocerebellar Hypoplasia 7

Hypoplasia, Pontocerebellar, Type 7
Non-Syndromic Pontocerebellar Hypoplasia

Pontoneocerebellar Hypoplasia

Pch

Pontoneocerebellar Atrophy
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Familial Papillary Or Follicular Thyroid Carcinoma

Fnmtc

Familial Pure Nonmedullary Thyroid Carcinoma

Familial Nonmedullary Thyroid Gland Carcinoma
Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis

Urbach-Wiethe Disease

Hyalinosis Cutis Et Mucosae

Lipid Proteinosis

Lipoproteinosis

Urbach Wiethe Disease

Lipoglycoproteinosis

Lipoidosis Cutis Et Mucosae

Lipoidproteinosis

Urbach-Wiethe Lipoid Proteinosis

Urbach-Wiethe Syndrome

LIP

Proteinosis Lipoid
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08457 MINPP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MINPP1 VGNC VGNC:74871
Canis familiaris MINPP1 VGNC VGNC:59061
Bos taurus MINPP1 VGNC VGNC:31480
Mus musculus MINPP1 MGD MGI:1336159
Rattus norvegicus MINPP1 RGD RGD:3089
Others MINPP1 NCBI