IER2 - immediate early response 2 Gene

Homo sapiens

Also known as CHX1; ETR101

Gene ID: 9592 | Gene type: protein coding

About IER2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:13,150,411-13,154,911 (from NCBI)

This gene has 3 transcripts (splice variants), 160 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 98.0), bone marrow (RPKM 95.1) and 24 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in cell motility and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

IER2 Products(1)

mRNA	Protein	Name
NM_004907.3	NP_004898.2	immediate early response gene 2 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell motility	IMP IMP: Inferred from mutant phenotype	22120713	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19584537	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22120713	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22120713	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IER2 Protein Structure

IER

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

immediate early response gene 2 protein

chxI protein homolog

Related Diseases

Diseases

Alias

Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 4	SRTD4
Atd4	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06547	IER2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IER2	VGNC	VGNC:62871
Bos taurus	IER2	VGNC	VGNC:30038
Canis familiaris	IER2	VGNC	VGNC:41868
Mus musculus	IER2	MGD	MGI:104815
Rattus norvegicus	IER2	RGD	RGD:1359581

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