PPM1F - protein phosphatase, Mg2+/Mn2+ dependent 1F Gene

Homo sapiens

Also known as CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase

Gene ID: 9647 | Gene type: protein coding

About PPM1F

Cytogenetic location: 22q11.22 Genomic coordinates (GRCh38): 22:21,919,425-21,952,848 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues and 16 paralogues. Ubiquitous expression in placenta (RPKM 16.9), spleen (RPKM 14.5) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-Activated Kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this Phosphatase. The overexpression of this Phosphatase or CAMK2G has been shown to mediate caspase-dependent Apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

PPM1F Products(2)

mRNA	Protein	Name
NM_001410836.1	NP_001397765.1	protein phosphatase 1F isoform 2
NM_014634.4	NP_055449.1	protein phosphatase 1F isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	11559703	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11559703	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	11559703	GOA
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	20016286	GOA
enables protein tyrosine/serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	24338362	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	20801214	GOA
involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11559703	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in negative regulation of cell-cell adhesion mediated by cadherin	IMP IMP: Inferred from mutant phenotype	24338362	GOA
involved in negative regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15140879	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11864573	GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15140879	GOA
involved in negative regulation of protein transport	IMP IMP: Inferred from mutant phenotype	24338362	GOA
involved in peptidyl-serine dephosphorylation	IMP IMP: Inferred from mutant phenotype	24338362	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	11559703	GOA
involved in positive regulation of cell migration	IGI IGI: Inferred from genetic interaction	26498692	GOA
involved in positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	11559703	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in positive regulation of growth	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	11864573	GOA
involved in positive regulation of stress fiber assembly	IGI IGI: Inferred from genetic interaction	26498692	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20016286	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	24338362	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11559703	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11864573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1F Protein Structure

PP2C

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1F

Ca(2+)/calmodulin-dependent protein kinase phosphatase

PPM1F Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPM1F	P49593	FEM1B	Homo sapiens	Q9UK73	Anti Tag CoIP	11559703
Cross	PPM1F	P49593	Camkk2	Mus musculus	Q8C078	Anti Tag CoIP	15140879

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sclerosing Cholangitis

Fibrosing Cholangitis	Cholangitis, Sclerosing
Primary Sclerosing Cholangitis

Hermaphroditism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10964	PPM1F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPM1F	VGNC	VGNC:33212
Felis catus	PPM1F	VGNC	VGNC:64311
Canis familiaris	PPM1F	VGNC	VGNC:44866
Macaca mulatta	PPM1F	VGNC	VGNC:76075
Rattus norvegicus	PPM1F	RGD	RGD:631363
Mus musculus	PPM1F	MGD	MGI:1918464
Others	PPM1F	NCBI

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