CD70 - CD70 molecule Gene

Homo sapiens

Also known as CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A

Gene ID: 970 | Gene type: protein coding

About CD70

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,581,648-6,591,150 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

CD70 Products(2)

mRNA	Protein	Name
NM_001252.5	NP_001243.1	CD70 antigen isoform 1
NM_001330332.2	NP_001317261.1	CD70 antigen isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12324477	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	8387892	GOA
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	28011863	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell mediated immunity	IMP IMP: Inferred from mutant phenotype	28011864	GOA
involved in B cell proliferation	IMP IMP: Inferred from mutant phenotype	28011864	GOA
involved in CD27 signaling pathway	IDA IDA: Inferred from direct assay	8387892	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	8387892	GOA
involved in T cell mediated immunity	IMP IMP: Inferred from mutant phenotype	28011864	GOA
involved in adaptive immune memory response involving T cells and B cells	IMP IMP: Inferred from mutant phenotype	28011863	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9177220	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	8387892	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11920585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD70 Protein Structure

TNF

0
100
193 a.a.

Protein Preferred Names

Protein Names

CD70 antigen

CD27 ligand

CD70 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD70	P32970	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	CD70	P32970	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	CD70	P32970	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD70 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72740	CD70 Protein, Human (HEK293, Fc)	P32970 (Q45-P193)	≥95%
HY-P75387	CD70 Protein, Human (HEK293, Fc-Avi)	P32970 (Q39-P193)	≥95%
HY-P78103	CD70 Trimer Protein, Human (Biotinylated, HEK293, His)	P32970 (L50-P193)	≥95%
HY-P78540	FITC-Labeled CD70 Protein, Human (HEK293, His)	P32970 (L50-P193)	≥95%
HY-P700035AF	Animal-Free CD70 Protein, Human (His)	P32970 (Q39-P193)	≥95%

Related Diseases

Diseases

Alias

Lymphoproliferative Syndrome 3

LPFS3	Cd70 Deficiency
Combined Immunodeficiency Due To Cd70 Deficiency	Cid Due To Cd70 Deficiency

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Lymphoproliferative Syndrome 2

Cd27 Deficiency	LPFS2
Combined Immunodeficiency Due To Cd27 Deficiency	Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Immunodeficiency 20

Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity	IMD20
Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Nk Cell Cytotoxicity	Cd16 Deficiency
Immunodeficiency, Type 20

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency	IMD16
Ox40 Deficiency	Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma
Combined Immunodeficiency With Impaired Immunity To Hhv-8	Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8
Immunodeficiency, Type 16

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160649	MC-Gly-Gly-Phe-Gly-GABA-Exatecan	Inhibitor	99.72%	Unkown
HY-RS02264	CD70 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD70	VGNC	VGNC:38970
Macaca mulatta	CD70	VGNC	VGNC:70705
Mus musculus	CD70	MGD	MGI:1195273
Bos taurus	CD70	VGNC	VGNC:52225
Rattus norvegicus	CD70	RGD	RGD:1588573
Felis catus	CD70	VGNC	VGNC:60636
Macaca fascicularis	CD70	NCBI	NCBI:102130438
Others	CD70	NCBI

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