DOCK4 - dedicator of cytokinesis 4 Gene

Homo sapiens

Gene ID: 9732 | Gene type: protein coding

About DOCK4

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:111,726,110-112,206,399 (from NCBI)

This gene has 18 transcripts (splice variants), 228 orthologues and 10 paralogues. Broad expression in lung (RPKM 9.6), brain (RPKM 9.0) and 23 other tissues.

Summary

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

DOCK4 Products(2)

mRNA	Protein	Name
NM_001363540.2	NP_001350469.1	dedicator of cytokinesis protein 4 isoform 2
NM_014705.4	NP_055520.3	dedicator of cytokinesis protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	16464467	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	16464467	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16464467	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	20679435	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	16464467	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	20679435	GOA
involved in negative regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	22158624	GOA
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	22158624	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	20679435	GOA
located in membrane	IDA IDA: Inferred from direct assay	20679435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK4 Protein Structure

SH3_2

DOCK-C2

DHR-2

0
400
800
1200
1600
1966 a.a.

Protein Preferred Names

Protein Names

dedicator of cytokinesis protein 4

DOCK4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DOCK4	Q8N1I0	GRB2	Homo sapiens	P62993	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Placenta Accreta

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Deafness, Autosomal Recessive 14

DFNB14	Autosomal Recessive Nonsyndromic Deafness 14
Autosomal Recessive Deafness 14

Dyslexia

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Deafness, Autosomal Recessive 17

DFNB17	Autosomal Recessive Nonsyndromic Deafness 17
Autosomal Recessive Deafness 17

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Specific Language Impairment

Language Impairment, Specific

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03926	DOCK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DOCK4	VGNC	VGNC:71866
Canis familiaris	DOCK4	VGNC	VGNC:40048
Rattus norvegicus	DOCK4	RGD	RGD:1561724
Mus musculus	DOCK4	MGD	MGI:1918006
Bos taurus	DOCK4	VGNC	VGNC:28158
Felis catus	DOCK4	VGNC	VGNC:61573

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