DOCK4 - dedicator of cytokinesis 4 Gene

Homo sapiens

Gene ID: 9732 | Gene type: protein coding

About DOCK4

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:111,726,110-112,206,399 (from NCBI)

This gene has 18 transcripts (splice variants), 228 orthologues and 10 paralogues. Broad expression in lung (RPKM 9.6), brain (RPKM 9.0) and 23 other tissues.

Summary

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

DOCK4 Products(2)

mRNA	Protein	Name
NM_001363540.2	NP_001350469.1	dedicator of cytokinesis protein 4 isoform 2
NM_014705.4	NP_055520.3	dedicator of cytokinesis protein 4 isoform 1

DOCK4 Protein Structure

SH3_2

DOCK-C2

DHR-2

0
400
800
1200
1600
1966 a.a.

Protein Preferred Names

Protein Names

dedicator of cytokinesis protein 4

Related Diseases

Diseases

Alias

Placenta Accreta

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Deafness, Autosomal Recessive 14

DFNB14	Autosomal Recessive Nonsyndromic Deafness 14
Autosomal Recessive Deafness 14

Dyslexia

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Deafness, Autosomal Recessive 17

DFNB17	Autosomal Recessive Nonsyndromic Deafness 17
Autosomal Recessive Deafness 17

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Specific Language Impairment

Language Impairment, Specific

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03926	DOCK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DOCK4	VGNC	VGNC:71866
Canis familiaris	DOCK4	VGNC	VGNC:40048
Rattus norvegicus	DOCK4	RGD	RGD:1561724
Mus musculus	DOCK4	MGD	MGI:1918006
Bos taurus	DOCK4	VGNC	VGNC:28158
Felis catus	DOCK4	VGNC	VGNC:61573

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