TOX - thymocyte selection associated high mobility group box Gene

Homo sapiens

Also known as TOX1

Gene ID: 9760 | Gene type: protein coding

About TOX

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:58,805,412-59,119,147 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 9.9), brain (RPKM 6.2) and 19 other tissues.

Summary

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

TOX Products(1)

mRNA	Protein	Name
NM_014729.3	NP_055544.1	thymocyte selection-associated high mobility group box protein TOX

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	21126536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX Protein Structure

HMG_box

0
100
200
300
400
526 a.a.

Protein Preferred Names

Protein Names

thymocyte selection-associated high mobility group box protein TOX

thymus high mobility group box protein TOX

TOX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TOX	O94900	KRTAP12-1	Homo sapiens	P59990	Validated Y2H	32296183
Intra	TOX	O94900	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	TOX	O94900	GRAP	Homo sapiens	Q13588	Validated Y2H	32296183
Intra	TOX	O94900	KRTAP26-1	Homo sapiens	Q6PEX3	Validated Y2H	32296183
Intra	TOX	O94900	DMRTB1	Homo sapiens	Q96MA1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis

Astigmatism

Parapsoriasis

Digitate Dermatosis	Parapsoriasis En Plaque
Parapsoriasis En Plaques

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0876	POPSO		≥95.0%	Unkown
HY-RS14908	TOX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14909	TOX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14910	TOX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14911	TOX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TOX	VGNC	VGNC:36228
Canis familiaris	TOX	VGNC	VGNC:47717
Rattus norvegicus	TOX	RGD	RGD:1310455
Felis catus	TOX	VGNC	VGNC:66458
Mus musculus	TOX	MGD	MGI:2181659
Macaca mulatta	TOX	VGNC	VGNC:79165
Macaca fascicularis	TOX	NCBI	NCBI:102136399
Susscrofa domestica	TOX	NCBI
Others	TOX	NCBI

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