DLGAP5 - DLG associated protein 5 Gene

Homo sapiens

Also known as DLG7; HURP

Gene ID: 9787 | Gene type: protein coding

About DLGAP5

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,148,135-55,191,585 (from NCBI)

This gene has 5 transcripts (splice variants), 173 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 9.4), testis (RPKM 9.1) and 12 other tissues.

Summary

Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in several cellular components, including centrosome; cytosol; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

DLGAP5 Products(2)

mRNA	Protein	Name
NM_001146015.2	NP_001139487.1	disks large-associated protein 5 isoform b
NM_014750.5	NP_055565.3	disks large-associated protein 5 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15145941	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12527899	GOA
located in spindle pole centrosome	IDA IDA: Inferred from direct assay	12527899	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLGAP5 Protein Structure

GKAP

0
200
400
600
800
846 a.a.

Protein Preferred Names

Protein Names

disks large-associated protein 5

DAP-5

Related Diseases

Diseases

Alias

Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1	Persistent Hyperinsulinemic Hypoglycemia Of Infancy
Familial Hyperinsulinemic Hypoglycemia 1	Congenital Hyperinsulinism
Phhi	Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Of Infancy	Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia
Nesidioblastosis Of Pancreas	Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis
Hyperinsulinism, Congenital	Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency	Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form
Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency	Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03805	DLGAP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DLGAP5	MGD	MGI:2183453
Canis familiaris	DLGAP5	VGNC	VGNC:39983
Bos taurus	DLGAP5	VGNC	VGNC:28091
Macaca mulatta	DLGAP5	VGNC	VGNC:71850
Rattus norvegicus	DLGAP5	RGD	RGD:1311247
Felis catus	DLGAP5	VGNC	VGNC:61517

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