SCRN1 - secernin 1 Gene

Homo sapiens

Also known as SES1

Gene ID: 9805 | Gene type: protein coding

About SCRN1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:29,920,103-29,990,289 (from NCBI)

This gene has 10 transcripts (splice variants), 132 orthologues and 2 paralogues. Broad expression in brain (RPKM 69.1), testis (RPKM 17.1) and 22 other tissues.

Summary

This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

SCRN1 Products(4)

mRNA	Protein	Name
NM_001145513.1	NP_001138985.1	secernin-1 isoform a
NM_001145514.1	NP_001138986.1	secernin-1 isoform b
NM_001145515.2	NP_001138987.1	secernin-1 isoform c
NM_014766.5	NP_055581.3	secernin-1 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear membrane	IDA IDA: Inferred from direct assay	10942595	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCRN1 Protein Structure

Peptidase_C69

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

secernin-1

SCRN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCRN1	Q12765	GORASP1	Homo sapiens	Q9BQQ3	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Osteosarcoma

Osteogenic Sarcoma Of Breast

Breast Extraskeletal Osteosarcoma

Gallbladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Gallbladder

Epidermoid Gallbladder Carcinoma

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12563	SCRN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCRN1	VGNC	VGNC:34366
Canis familiaris	SCRN1	VGNC	VGNC:54794
Macaca mulatta	SCRN1	VGNC	VGNC:77083
Mus musculus	SCRN1	MGD	MGI:1917188
Felis catus	SCRN1	VGNC	VGNC:80713
Rattus norvegicus	SCRN1	RGD	RGD:1560999

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