CTIF - cap binding complex dependent translation initiation factor Gene

Homo sapiens

Also known as Gm672; KIAA0427

Gene ID: 9811 | Gene type: protein coding

About CTIF

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:48,539,031-48,863,217 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 205 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 23.6), brain (RPKM 13.3) and 22 other tissues.

Summary

CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

CTIF Products(2)

mRNA	Protein	Name
NM_001142397.2	NP_001135869.1	CBP80/20-dependent translation initiation factor isoform 2
NM_014772.3	NP_055587.1	CBP80/20-dependent translation initiation factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19648179	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	19648179	GOA
involved in regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	19648179	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19648179	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTIF Protein Structure

MIF4G

0
100
200
300
400
500
598 a.a.

Protein Preferred Names

Protein Names

CBP80/20-dependent translation initiation factor

Related Diseases

Diseases

Alias

Orofacial Cleft 11

OFC11	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 11
Nonsyndromic Cleft Lip With Or Without Cleft Palate 11	Non-Syndromic Orofacial Cleft 11
Chcl	Cleft Lip Congenital Healed
Congenital Healed Cleft Lip	Non-Syndromic Cleft Lip/Palate 11
Non-Syndromic Cleft Lip With Or Without Cleft Palate 11	Orofacial Cleft, Type 11
Cleft Lip, Congenital Healed

Hernia, Hiatus

Hiatal Hernia	Hiatus Hernia
Diaphragmatic - Hiatus -Hernia	Hernia, Hiatal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03298	CTIF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CTIF	RGD	RGD:1311887
Canis familiaris	CTIF	VGNC	VGNC:39698
Mus musculus	CTIF	MGD	MGI:2685518
Bos taurus	CTIF	VGNC	VGNC:27797
Felis catus	CTIF	VGNC	VGNC:61252
Macaca mulatta	CTIF	VGNC	VGNC:110334

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