RGP1 - RGP1 homolog, RAB6A GEF complex partner 1 Gene

Homo sapiens

Also known as KIAA0258

Gene ID: 9827 | Gene type: protein coding

About RGP1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,749,287-35,790,428 (from NCBI)

This gene has 2 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in thyroid (RPKM 11.4), kidney (RPKM 9.6) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of cellular protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Located in cytosol and plasma membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]

RGP1 Products(1)

mRNA	Protein	Name
NM_001080496.3	NP_001073965.2	RAB6A-GEF complex partner protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	23091056	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22458338	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	23091056	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	23091056	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	23091056	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	23091056	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex	IDA IDA: Inferred from direct assay	23091056	GOA
located in cytosol	IDA IDA: Inferred from direct assay	23091056	GOA
located in membrane	IDA IDA: Inferred from direct assay	23091056	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23091056	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGP1 Protein Structure

Rgp1

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

RAB6A-GEF complex partner protein 2

RGP1 retrograde golgi transport homolog

RGP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGP1	Q92546	RFPL3	Homo sapiens	O75679	Y2H Array	32296183
Intra	RGP1	Q92546	RFPL3	Homo sapiens	O75679	Y2H Prey Pooling	32296183
Cross	RGP1	Q92546	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11897	RGP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RGP1	RGD	RGD:1311757
Bos taurus	RGP1	VGNC	VGNC:33908
Felis catus	RGP1	VGNC	VGNC:64593
Canis familiaris	RGP1	VGNC	VGNC:45517
Mus musculus	RGP1	MGD	MGI:1915956

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