2. Gene
  3. PAN2 - poly(A) specific ribonuclease subunit PAN2 Gene

PAN2 - poly(A) specific ribonuclease subunit PAN2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as USP52

Gene ID: 9924 | Gene type: protein coding

About PAN2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,316,936-56,334,000 (from NCBI)

This gene has 21 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 18.6) and 25 other tissues.

Summary

This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PAN2 Products(13)

mRNA Protein Name
NM_001127460.4 NP_001120932.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001166279.3 NP_001159751.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 2
NM_001394699.1 NP_001381628.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001394700.1 NP_001381629.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3
NM_001394701.1 NP_001381630.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394702.1 NP_001381631.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394703.1 NP_001381632.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 5
NM_001394704.1 NP_001381633.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 6
NM_001394705.1 NP_001381634.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 7
NM_001394706.1 NP_001381635.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394707.1 NP_001381636.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394708.1 NP_001381637.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 9
NM_014871.6 NP_055686.4 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
14583602 GOA
enables poly(A)-specific ribonuclease activity IDA
IDA: Inferred from direct assay
14583602 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14583602 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PAN complex IDA
IDA: Inferred from direct assay
14583602 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAN2 Protein Structure

UCH_1

UCH_1: Ubiquitin carboxyl-terminal hydrolase (517 - 898)

RNase_T

RNase_T: Exonuclease (975 - 1147)

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  • 1202 a.a.
Protein Preferred Names Protein Names

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

PAB-dependent poly(A)-specific ribonuclease subunit 2

PAN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PAN2 Q504Q3 PAN3 Homo sapiens Q58A45
Anti Tag CoIP
14583602
Intra
PAN2 Q504Q3 PAN3 Homo sapiens Q58A45
Anti Tag CoIP
19615732
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10014 PAN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAN2 MGD MGI:1918984
Bos taurus PAN2 VGNC VGNC:58444
Macaca mulatta PAN2 VGNC VGNC:100085
Rattus norvegicus PAN2 RGD RGD:1303301
Canis familiaris PAN2 VGNC VGNC:54530
Others PAN2 NCBI