2. Gene
  3. PAN2 - poly(A) specific ribonuclease subunit PAN2 Gene

PAN2 - poly(A) specific ribonuclease subunit PAN2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as USP52

Gene ID: 9924 | Gene type: protein coding

About PAN2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,316,936-56,334,000 (from NCBI)

This gene has 21 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 18.6) and 25 other tissues.

Summary

This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) Nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PAN2 Products(13)

mRNA Protein Name
NM_001127460.4 NP_001120932.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001166279.3 NP_001159751.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 2
NM_001394699.1 NP_001381628.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001394700.1 NP_001381629.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3
NM_001394701.1 NP_001381630.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394702.1 NP_001381631.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394703.1 NP_001381632.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 5
NM_001394704.1 NP_001381633.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 6
NM_001394705.1 NP_001381634.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 7
NM_001394706.1 NP_001381635.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394707.1 NP_001381636.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394708.1 NP_001381637.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 9
NM_014871.6 NP_055686.4 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
14583602 GOA
enables poly(A)-specific ribonuclease activity IDA
IDA: Inferred from direct assay
14583602 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14583602 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PAN complex IDA
IDA: Inferred from direct assay
14583602 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAN2 Protein Structure

UCH_1

UCH_1: Ubiquitin carboxyl-terminal hydrolase (517 - 898)

RNase_T

RNase_T: Exonuclease (975 - 1147)

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  • 1202 a.a.
Protein Preferred Names Protein Names

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

PAB-dependent poly(A)-specific ribonuclease subunit 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10014 PAN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAN2 MGD MGI:1918984
Bos taurus PAN2 VGNC VGNC:58444
Macaca mulatta PAN2 VGNC VGNC:100085
Rattus norvegicus PAN2 RGD RGD:1303301
Canis familiaris PAN2 VGNC VGNC:54530
Others PAN2 NCBI