2. Anti-infection
  3. Antibiotic Bacterial
  4. Gentamicin C1a

Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex.

For research use only. We do not sell to patients.

Gentamicin C1a Chemical Structure

Gentamicin C1a Chemical Structure

CAS No. : 26098-04-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Gentamicin C1a:

Gentamicin C1a Related Antibodies

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Description

Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 CC50
> 300 μM
Compound: Gentamicin
Cytotoxicity against HEK293 cells after 24 hrs by resazurin assay
Cytotoxicity against HEK293 cells after 24 hrs by resazurin assay
[PMID: 26734854]
HepG2 CC50
> 300 μM
Compound: Gentamicin
Cytotoxicity against human HepG2 cells after 24 hrs by resazurin assay
Cytotoxicity against human HepG2 cells after 24 hrs by resazurin assay
[PMID: 26734854]
HK-2 CC50
33 μg/mL
Compound: Gentamicin
Cytotoxicity against HK2 cells assessed as LDH release by Western blot analysis
Cytotoxicity against HK2 cells assessed as LDH release by Western blot analysis
[PMID: 26734854]
HK-2 CC50
33 μg/mL
Compound: Gentamicin
Cytotoxicity against HK2 cells assessed as GGT release by Western blot analysis
Cytotoxicity against HK2 cells assessed as GGT release by Western blot analysis
[PMID: 26734854]
In Vitro

Gentamicin C1a inhibits Escherichia coli, P. aeruginosa and S. aureus with an IC50 value of 1 mg/mL[2].
Gentamicin C1a (2 mM, 48 h) has no effect on viability of OC-k3 cell[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gentamicin C1a Related Antibodies
In Vivo

Gentamicin C1a (4 mg/kg, intravenous bolus dose, single) shows a mean residence time of 84 min, CL value of 1.81 mL/min/kg in beagles[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

449.54

Formula

C19H39N5O7
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O[C@@H]([C@@H]([C@H](C[C@H]1N)N)O[C@H]2O[C@@H](CC[C@H]2N)CN)[C@H]1O[C@@H]3[C@@H]([C@H]([C@@](O)(CO3)C)NC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (556.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2245 mL 11.1225 mL 22.2450 mL
5 mM 0.4449 mL 2.2245 mL 4.4490 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (584 KB)

COA (252 KB) HNMR (297 KB) MS (83 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2245 mL 11.1225 mL 22.2450 mL 55.6124 mL
5 mM 0.4449 mL 2.2245 mL 4.4490 mL 11.1225 mL
10 mM 0.2224 mL 1.1122 mL 2.2245 mL 5.5612 mL
15 mM 0.1483 mL 0.7415 mL 1.4830 mL 3.7075 mL
20 mM 0.1112 mL 0.5561 mL 1.1122 mL 2.7806 mL
25 mM 0.0890 mL 0.4449 mL 0.8898 mL 2.2245 mL
30 mM 0.0741 mL 0.3707 mL 0.7415 mL 1.8537 mL
40 mM 0.0556 mL 0.2781 mL 0.5561 mL 1.3903 mL
50 mM 0.0445 mL 0.2224 mL 0.4449 mL 1.1122 mL
60 mM 0.0371 mL 0.1854 mL 0.3707 mL 0.9269 mL
80 mM 0.0278 mL 0.1390 mL 0.2781 mL 0.6952 mL
100 mM 0.0222 mL 0.1112 mL 0.2224 mL 0.5561 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gentamicin C1a Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gentamicin C1a26098-04-4AntibioticBacterialAntibacterialGentamicinInhibitorinhibitorinhibit

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