2. Protein Tyrosine Kinase/RTK
  3. FLT3 TAM Receptor
  4. Gilteritinib-d8

Gilteritinib-d8  (Synonyms: ASP2215-d8)

Cat. No.: HY-12432S1 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

Gilteritinib-d8 is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

For research use only. We do not sell to patients.

Gilteritinib-d<sub>8</sub> Chemical Structure

Gilteritinib-d8 Chemical Structure

CAS No. : 2377109-74-3

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1 mg USD 1550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Gilteritinib-d8:

Gilteritinib-d8 Related Antibodies

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Axl Mer Tyro3

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  • Purity & Documentation

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Description

Gilteritinib-d8 is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gilteritinib-d8 Related Antibodies
Molecular Weight

560.76

Formula

C29H36D8N8O3
CAS No.
Unlabeled CAS

1254053-43-4
Appearance

Solid

Color

White to yellow

SMILES

NC(C(C(NC1=CC(OC)=C(N2CCC(N3C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C3([2H])[2H])C)CC2)C=C1)=N4)=NC(CC)=C4NC5CCOCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (178.33 mM; ultrasonic and adjust pH to 2 with HCl)

Ethanol : 100 mg/mL (178.33 mM; ultrasonic and adjust pH to 2 with HCl)

DMSO : 2 mg/mL (3.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 2 mg/mL (3.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7833 mL 8.9165 mL 17.8329 mL
5 mM 0.3567 mL 1.7833 mL 3.5666 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO / Ethanol / Ethanol 1 mM 1.7833 mL 8.9165 mL 17.8329 mL 44.5824 mL
Ethanol / Ethanol 5 mM 0.3567 mL 1.7833 mL 3.5666 mL 8.9165 mL
10 mM 0.1783 mL 0.8916 mL 1.7833 mL 4.4582 mL
15 mM 0.1189 mL 0.5944 mL 1.1889 mL 2.9722 mL
20 mM 0.0892 mL 0.4458 mL 0.8916 mL 2.2291 mL
25 mM 0.0713 mL 0.3567 mL 0.7133 mL 1.7833 mL
30 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4861 mL
40 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1146 mL
50 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.8916 mL
60 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7430 mL
80 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.5573 mL
100 mM 0.0178 mL 0.0892 mL 0.1783 mL 0.4458 mL
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Gilteritinib-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gilteritinib-d82377109-74-3ASP2215-d8FLT3TAM ReceptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Tyro3AxlMerInhibitorinhibitorinhibit

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