2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Giripladib

Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research.

For research use only. We do not sell to patients.

Giripladib Chemical Structure

Giripladib Chemical Structure

CAS No. : 865200-20-0

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Based on 1 publication(s) in Google Scholar

Giripladib Related Antibodies

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Phospholipase A PLD Phospholipase C

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Description

Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2].

IC50 & Target

cPLA2α

 

Clinical Trial
Molecular Weight

745.25

Formula

C41H36ClF3N2O4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC=C(CCCC2=C(CCNS(=O)(CC3=C(C(F)(F)F)C=CC=C3)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(C=C6)Cl)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (167.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3418 mL 6.7092 mL 13.4183 mL
5 mM 0.2684 mL 1.3418 mL 2.6837 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3418 mL 6.7092 mL 13.4183 mL 33.5458 mL
5 mM 0.2684 mL 1.3418 mL 2.6837 mL 6.7092 mL
10 mM 0.1342 mL 0.6709 mL 1.3418 mL 3.3546 mL
15 mM 0.0895 mL 0.4473 mL 0.8946 mL 2.2364 mL
20 mM 0.0671 mL 0.3355 mL 0.6709 mL 1.6773 mL
25 mM 0.0537 mL 0.2684 mL 0.5367 mL 1.3418 mL
30 mM 0.0447 mL 0.2236 mL 0.4473 mL 1.1182 mL
40 mM 0.0335 mL 0.1677 mL 0.3355 mL 0.8386 mL
50 mM 0.0268 mL 0.1342 mL 0.2684 mL 0.6709 mL
60 mM 0.0224 mL 0.1118 mL 0.2236 mL 0.5591 mL
80 mM 0.0168 mL 0.0839 mL 0.1677 mL 0.4193 mL
100 mM 0.0134 mL 0.0671 mL 0.1342 mL 0.3355 mL
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Giripladib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Giripladib865200-20-0PLA-695PLA695PLA 695PhospholipaseOsteoarthritisBCSCstumorigenesisbreast cancer stem cellscytosolic phospholipase A2Inhibitorinhibitorinhibit

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