2. Apoptosis PI3K/Akt/mTOR Epigenetics Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Apoptosis AMPK Reactive Oxygen Species
  4. GL-V9

GL-V9 inhibits proliferation of HepG2 cell (IC50 is 35.2 μM) through induction of apoptosis and cell cycle arrest at G2/M phase. GL-V9 regulates mitochondrial membrane potential and increases the production of intracellular reactive oxygen species. GL-V9 inhibits the pentose phosphate pathway (PPP), enhances fatty acid oxidation (FAO) through activation of AMPK, and thus inhibits the metastasis of cancer cells. GL-V9 exhibits antitumor efficacy in mouse model.

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GL-V9 Chemical Structure

GL-V9 Chemical Structure

CAS No. : 1178583-19-1

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GL-V9 Related Antibodies

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Description

GL-V9 inhibits proliferation of HepG2 cell (IC50 is 35.2 μM) through induction of apoptosis and cell cycle arrest at G2/M phase. GL-V9 regulates mitochondrial membrane potential and increases the production of intracellular reactive oxygen species. GL-V9 inhibits the pentose phosphate pathway (PPP), enhances fatty acid oxidation (FAO) through activation of AMPK, and thus inhibits the metastasis of cancer cells. GL-V9 exhibits antitumor efficacy in mouse model[1][2].

Molecular Weight

409.47

Formula

C24H27NO5
CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(OCCCCN4CCCC4)=CC(O)=C13
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GL-V9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GL-V91178583-19-1ApoptosisAMPKReactive Oxygen SpeciesAMP-activated protein kinaseHepG2ICR mouseH22MDA-MB-231Hepatocellular carcinomaTNBCInhibitorinhibitorinhibit

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