1. Apoptosis PI3K/Akt/mTOR Epigenetics Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Apoptosis AMPK Reactive Oxygen Species
  3. GL-V9

GL-V9 inhibits proliferation of HepG2 cell (IC50 is 35.2 μM) through induction of apoptosis and cell cycle arrest at G2/M phase. GL-V9 regulates mitochondrial membrane potential and increases the production of intracellular reactive oxygen species. GL-V9 inhibits the pentose phosphate pathway (PPP), enhances fatty acid oxidation (FAO) through activation of AMPK, and thus inhibits the metastasis of cancer cells. GL-V9 exhibits antitumor efficacy in mouse model.

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GL-V9 Chemical Structure

GL-V9 Chemical Structure

CAS No. : 1178583-19-1

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Description

GL-V9 inhibits proliferation of HepG2 cell (IC50 is 35.2 μM) through induction of apoptosis and cell cycle arrest at G2/M phase. GL-V9 regulates mitochondrial membrane potential and increases the production of intracellular reactive oxygen species. GL-V9 inhibits the pentose phosphate pathway (PPP), enhances fatty acid oxidation (FAO) through activation of AMPK, and thus inhibits the metastasis of cancer cells. GL-V9 exhibits antitumor efficacy in mouse model[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.53 μM
Compound: 3c
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
HepG2 IC50
3.61 μM
Compound: 3c
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
Molecular Weight

409.47

Formula

C24H27NO5

CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(OCCCCN4CCCC4)=CC(O)=C13

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GL-V9
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