2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Glecirasib

Glecirasib  (Synonyms: JAB-21822; KRAS G12C inhibitor 36)

Cat. No.: HY-143589 Purity: 98.89%
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Glecirasib (Compound 1-2; JAB-21822) is an orally active and potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. Glecirasib has the potential for the research of KRAS G12C-mediated cancer.

For research use only. We do not sell to patients.

Glecirasib Chemical Structure

Glecirasib Chemical Structure

CAS No. : 2657613-87-9

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Based on 1 publication(s) in Google Scholar

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Description

Glecirasib (Compound 1-2; JAB-21822) is an orally active and potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. Glecirasib has the potential for the research of KRAS G12C-mediated cancer[1][2][3][4].

In Vivo

Glecirasib (10 mg/kg, p.o., daily for ~3 weeks) inhibits tumor growth in NCI-H1373 xenograft mice model[1][3].
Glecirasib (400 mg/kg, p.o., daily for 22 days) has no influence on the body weight, showing good safety in NCI-H1373 xenograft mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H1373 xenograft mice model[1]
Dosage: 400 mg/kg
Administration: p.o., daily for 22 days
Result: Had no significant change on the weight of the mice.
Animal Model: NCI-H1373 xenograft mice model[1]
Dosage: 10 mg/kg
Administration: p.o., daily for ~3 weeks
Result: Decreased the tumor volume in the NCI-H1373 xenograft mice.
Molecular Weight

640.03

Formula

C31H26ClF4N7O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=C(N2CCN(CC2)C(C=C)=O)C3=C(N=C(C4=C(N)C(F)=C(F)C(F)=C4F)C(Cl)=C3)N(C5=C(C)C=CN=C5C(C)C)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.89%

SDS (251 KB)

COA (255 KB) HNMR (225 KB) RP-HPLC (142 KB) LCMS (110 KB)

Handling Instructions (2659 KB)
References
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Glecirasib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glecirasib2657613-87-9JAB-21822 KRAS G12C inhibitor 36JAB21822JAB 21822RasKRAS G12CintracellulargrowthcancerInhibitorinhibitorinhibit

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