2. Immunology/Inflammation
  3. Glycoprotein VI
  4. Glenzocimab

Glenzocimab  (Synonyms: ACT017)

Cat. No.: HY-P99644 Purity: ≥99.0%
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ACT017 is a Fab fragment of humanized anti-GPVI monoclonal antibody. ACT017 inhibits collagen-induced platelet aggregation. ACT017 has the potential for the research of acute ischemic stroke.

For research use only. We do not sell to patients.

CAS No. : 2101829-58-5

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Based on 1 publication(s) in Google Scholar

Glenzocimab Related Antibodies

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Description

ACT017 is a Fab fragment of humanized anti-GPVI monoclonal antibody. ACT017 inhibits collagen-induced platelet aggregation. ACT017 has the potential for the research of acute ischemic stroke[1][2].

In Vitro

ACT017 (0-100000 ng/mL) inhibits GPVI-Fc binding to collagen immobilized on a microtitration plate with an IC50 of 1.37 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glenzocimab Related Antibodies
In Vivo

ACT017 (1-8 mg/kg; i.v.) inhibits collagen-induced platelet aggregation in cynomolgus monkeys[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[2]
Dosage: 1-8 mg/kg
Administration: I.v.
Result: Reversibly inhibited collagen-induced platelet aggregation, at 2 to 8 mg/kg doses, collagen-induced platelet aggregation measured 0.5 hour after the end of the administration was fully inhibited for all cynomolgus.
Clinical Trial
Molecular Weight

64.29

Formula

CHT17
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[*][CH]([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])([3H])[3H]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Fab-G1-kappa
Biological Activity
  • Immobilized GPVI Protein, Human can bind Glenzocimab. The EC50 for this effect is 7.19 ng/mL.
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (232 KB) SDS-PAGE (80 KB) SEC-HPLC (154 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Glenzocimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glenzocimab2101829-58-5ACT017ACT 017ACT-017Glycoprotein VIGPVIInhibitorinhibitorinhibit

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