2. GPCR/G Protein
  3. GCGR
  4. GLP-1R modulator C16

GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).

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GLP-1R modulator C16 Chemical Structure

GLP-1R modulator C16 Chemical Structure

CAS No. : 875005-43-9

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Based on 1 publication(s) in Google Scholar

GLP-1R modulator C16 Related Antibodies

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Description

GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).

Molecular Weight

408.89

Formula

C21H26ClFN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C=CC(CNCCN2CCOCC2)=C1)OCC3=C(C=CC=C3Cl)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (122.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4456 mL 12.2282 mL 24.4565 mL
5 mM 0.4891 mL 2.4456 mL 4.8913 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4456 mL 12.2282 mL 24.4565 mL 61.1411 mL
5 mM 0.4891 mL 2.4456 mL 4.8913 mL 12.2282 mL
10 mM 0.2446 mL 1.2228 mL 2.4456 mL 6.1141 mL
15 mM 0.1630 mL 0.8152 mL 1.6304 mL 4.0761 mL
20 mM 0.1223 mL 0.6114 mL 1.2228 mL 3.0571 mL
25 mM 0.0978 mL 0.4891 mL 0.9783 mL 2.4456 mL
30 mM 0.0815 mL 0.4076 mL 0.8152 mL 2.0380 mL
40 mM 0.0611 mL 0.3057 mL 0.6114 mL 1.5285 mL
50 mM 0.0489 mL 0.2446 mL 0.4891 mL 1.2228 mL
60 mM 0.0408 mL 0.2038 mL 0.4076 mL 1.0190 mL
80 mM 0.0306 mL 0.1529 mL 0.3057 mL 0.7643 mL
100 mM 0.0245 mL 0.1223 mL 0.2446 mL 0.6114 mL
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GLP-1R modulator C16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLP-1R modulator C16875005-43-9GCGRGlucagon ReceptorInhibitorinhibitorinhibit

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