Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br

Name: Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br
Brand: MedChemExpress
SKU: HY-153345
Rating: 4.5 (1 reviews)

Cat. No.: HY-153345 Purity: 99.67%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br is an Drug-linker conjugates for ADC that can be used as a reaction reagent for the synthesis of anti-CD40 antibody agent conjugates (ADCs).

For research use only. We do not sell to patients.

Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br Chemical Structure

CAS No. : 2345733-40-4

Size	Price	Stock	Quantity
1 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2500	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 4000	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 8000	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

948.74

Formula

C₄₃H₄₉BrF₂N₃O₁₂P

CAS No.

2345733-40-4

Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C([C@H](C4)F)=CC(C=C5)=O)C)F)([H])C[C@@]1([H])O[C@@H](C6=CC=C(C=C6)CC7=CC(NC([C@H](C)NC([C@H](C)NC(CBr)=O)=O)=O)=CC=C7)O2)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (105.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0540 mL	5.2701 mL	10.5403 mL
5 mM	0.2108 mL	1.0540 mL	2.1081 mL
10 mM	0.1054 mL	0.5270 mL	1.0540 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (2.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.67%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (252 KB) HNMR (350 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Hobson A D, et al. Anti-cd40 antibody drug conjugates. World Intellectual Property Organization. WO2019106608.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0540 mL	5.2701 mL	10.5403 mL	26.3507 mL
	5 mM	0.2108 mL	1.0540 mL	2.1081 mL	5.2701 mL
	10 mM	0.1054 mL	0.5270 mL	1.0540 mL	2.6351 mL
	15 mM	0.0703 mL	0.3513 mL	0.7027 mL	1.7567 mL
	20 mM	0.0527 mL	0.2635 mL	0.5270 mL	1.3175 mL
	25 mM	0.0422 mL	0.2108 mL	0.4216 mL	1.0540 mL
	30 mM	0.0351 mL	0.1757 mL	0.3513 mL	0.8784 mL
	40 mM	0.0264 mL	0.1318 mL	0.2635 mL	0.6588 mL
	50 mM	0.0211 mL	0.1054 mL	0.2108 mL	0.5270 mL
	60 mM	0.0176 mL	0.0878 mL	0.1757 mL	0.4392 mL
	80 mM	0.0132 mL	0.0659 mL	0.1318 mL	0.3294 mL
	100 mM	0.0105 mL	0.0527 mL	0.1054 mL	0.2635 mL