2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate.

For research use only. We do not sell to patients.

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Chemical Structure

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Chemical Structure

CAS No. : 1599440-20-6

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Other Forms of Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH:

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Related Antibodies

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Description

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Related Antibodies
Molecular Weight

423.42

Formula

C18H25N5O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(COCNC(CNC([C@@H](NC(CNC(CN)=O)=O)CC1=CC=CC=C1)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (2.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3617 mL 11.8086 mL 23.6172 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

SDS (393 KB)

COA (244 KB) HNMR (228 KB) RP-HPLC (258 KB) MS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3617 mL 11.8086 mL 23.6172 mL 59.0430 mL
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Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH1599440-20-6ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
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