2. Apoptosis
  3. Apoptosis
  4. (Gly14)-Humanin (human) (acetate)

(Gly14)-Humanin (human) (acetate)  (Synonyms: 14-Glycine-Humanin (human) (acetate))

Cat. No.: HY-P3993A Purity: 99.86%
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(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions.

For research use only. We do not sell to patients.

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(Gly14)-Humanin (human) (acetate) Chemical Structure

(Gly14)-Humanin (human) (acetate) Chemical Structure

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Based on 1 publication(s) in Google Scholar

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(Gly14)-Humanin (human) (acetate) Related Antibodies

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Description

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions[1][2].

In Vitro

(Gly14)-Humanin (human) acetate (0.1-10 μM; 72 hours) significantly increases cell viability, reduced nuclear fluorescence of HUVECs, the levels of cleaved PARP, ROS formation and the ratio of bax/bcl-2 compared with treatment with high glucose (HG) for 72h. And reduces mRNA level of bax and increases mRNA level of bcl-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Gly14)-Humanin (human) (acetate) Related Antibodies
In Vivo

(Gly14)-Humanin (human) acetate acetate (0.1 μg/5 μL; i.c.v.; once) decreases cells with plasmalemma permeability in the injured cortex and hippocampus, reduces brain lesion volume, improves motor performance and ameliorates performance in the Morris water maze test[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2657.21 (free acid)

Formula

C118H202N34O31S2.xC2H4O2
Appearance

Solid

Color

White to off-white

Sequence

Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Sequence Shortening

MAPRGFSCLLLLTGEIDLPVKRRA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

COA (242 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
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(Gly14)-Humanin (human) (acetate) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Gly14)-Humanin (human) (acetate)14-Glycine-Humanin (human) (acetate)Apoptosisbaxbcl-2PARPROSanti-apoptoticneuroprotectiveInhibitorinhibitorinhibit

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