2. Metabolic Enzyme/Protease
  3. FXR
  4. Glyco-Obeticholic acid

Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist.

For research use only. We do not sell to patients.

Glyco-Obeticholic acid Chemical Structure

Glyco-Obeticholic acid Chemical Structure

CAS No. : 863239-60-5

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Other Forms of Glyco-Obeticholic acid:

Glyco-Obeticholic acid Related Antibodies

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Description

Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist[1].

In Vitro

Obeticholic acid is conjugated with glycine in the liver to form glycol-obeticholic acid, which is secreted into bile. Microorganisms in the ileum and colon can deconjugate glyco-obeticholic acid, converting it into the parent drug, which may then be reabsorbed or excreted in faeces[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glyco-Obeticholic acid Related Antibodies
Molecular Weight

477.68

Formula

C28H47NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (20.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0935 mL 10.4673 mL 20.9345 mL
5 mM 0.4187 mL 2.0935 mL 4.1869 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0935 mL 10.4673 mL 20.9345 mL 52.3363 mL
5 mM 0.4187 mL 2.0935 mL 4.1869 mL 10.4673 mL
10 mM 0.2093 mL 1.0467 mL 2.0935 mL 5.2336 mL
15 mM 0.1396 mL 0.6978 mL 1.3956 mL 3.4891 mL
20 mM 0.1047 mL 0.5234 mL 1.0467 mL 2.6168 mL
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Glyco-Obeticholic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glyco-Obeticholic acid863239-60-5FXRNR1H4metabolitelivermicroorganismsileumcolonInhibitorinhibitorinhibit

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