2. Stem Cell/Wnt
  3. Porcupine Wnt
  4. GNF-1331

GNF-1331 (compound 19) is a potent, selective and orally bioavailable porcupine inhibitor (IC50=12 nM). GNF-1331 blocks Wnt ligand secretion and subsequent Wnt signaling activity, and induces significant antitumor effects in the mouse MMTV-WNT1 xenograft tumor model.

For research use only. We do not sell to patients.

GNF-1331 Chemical Structure

GNF-1331 Chemical Structure

CAS No. : 603101-22-0

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GNF-1331 Related Antibodies

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Description

GNF-1331 (compound 19) is a potent, selective and orally bioavailable porcupine inhibitor (IC50=12 nM). GNF-1331 blocks Wnt ligand secretion and subsequent Wnt signaling activity, and induces significant antitumor effects in the mouse MMTV-WNT1 xenograft tumor model[1].

Molecular Weight

440.54

Formula

C20H20N6O2S2
CAS No.
SMILES

O=C(CSC1=NN=C(N1CCC)C2=CC=NC=C2)NC3=NC4=CC=C(C=C4S3)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GNF-1331 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNF-1331603101-22-0GNF1331GNF 1331PorcupineWntinhibitoranti-tumorMMTV-WNT1 xenograft tumor modelInhibitorinhibit

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