Gomisin M1 (Synonyms: (±)-Gomisin M1)

Name: Gomisin M1
Brand: MedChemExpress
SKU: HY-N1529
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1529 Purity: 99.56%: FAQs
Data Sheet SDS COA Handling Instructions

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Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM.

For research use only. We do not sell to patients.

Gomisin M1 Chemical Structure

CAS No. : 82467-50-3

Size	Price	Stock	Quantity
1 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2000	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM^[1].

IC₅₀ & Target^[1]

HIV-1

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 23738539]
H9	EC₅₀	< 0.65 μM Compound: 4	Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA	[PMID: 17190445]
H9	IC₅₀	44.5 μM Compound: 4	Cytotoxicity against human H9 cells after 4 days Cytotoxicity against human H9 cells after 4 days	[PMID: 17190445]
HCT-116	IC₅₀	55.38 μM Compound: GM	Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HeLa	IC₅₀	17.15 μM Compound: GM	Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay	[PMID: 34038111]
HeLa	IC₅₀	32.83 μM Compound: GM	Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HepG2	IC₅₀	27.26 μM Compound: GM	Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
Huh-7	IC₅₀	32.23 μM Compound: GM	Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MCF7	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 23738539]
MDA-MB-231	IC₅₀	56.61 μM Compound: GM	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MHCC97	IC₅₀	24.75 μM Compound: GM	Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
NB-4	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human NB4 cells after 3 days by MTT assay Cytotoxicity against human NB4 cells after 3 days by MTT assay	[PMID: 23738539]
PC-3	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human PC3 cells after 3 days by MTT assay Cytotoxicity against human PC3 cells after 3 days by MTT assay	[PMID: 23738539]
SH-SY5Y	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay	[PMID: 23738539]
SK-HEP1	IC₅₀	20.56 μM Compound: GM	Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]

In Vitro

Gomisin M1 ((±)-Gomisin M1) (4 days) shows anti-HIV-1 activity with an EC₅₀ of <0.65 μM in H9 T cell lines and therapeutic index (TI) is >68^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

386.44

Formula

C₂₂H₂₆O₆

CAS No.

82467-50-3

Appearance

Solid

Color

White to off-white

SMILES

OC1=C(C2=C3C=C4OCOC4=C2OC)C(CC(C)C(C)C3)=CC(OC)=C1OC

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 17.2 mg/mL (44.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5877 mL	12.9386 mL	25.8772 mL
5 mM	0.5175 mL	2.5877 mL	5.1754 mL
10 mM	0.2588 mL	1.2939 mL	2.5877 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (260 KB) HNMR (222 KB) LCMS (78 KB)

Handling Instructions (2659 KB)

References

[1]. Chen M, et al. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. J Nat Prod. 2006 Dec;69(12):1697-701. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5877 mL	12.9386 mL	25.8772 mL	64.6931 mL
	5 mM	0.5175 mL	2.5877 mL	5.1754 mL	12.9386 mL
	10 mM	0.2588 mL	1.2939 mL	2.5877 mL	6.4693 mL
	15 mM	0.1725 mL	0.8626 mL	1.7251 mL	4.3129 mL
	20 mM	0.1294 mL	0.6469 mL	1.2939 mL	3.2347 mL
	25 mM	0.1035 mL	0.5175 mL	1.0351 mL	2.5877 mL
	30 mM	0.0863 mL	0.4313 mL	0.8626 mL	2.1564 mL
	40 mM	0.0647 mL	0.3235 mL	0.6469 mL	1.6173 mL

Gomisin M1 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gomisin M182467-50-3(±)-Gomisin M1Gomisin M 1Gomisin M-1HIVHuman immunodeficiency virusH9 THIV-1Inhibitorinhibitorinhibit

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Gomisin M1 (Synonyms: (±)-Gomisin M1)

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Gomisin M1 Related Antibodies

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•Related Screening Libraries:

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View All HIV Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Gomisin M1 Related Antibodies

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Complete Stock Solution Preparation Table

Gomisin M1 Related Classifications

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