Goniothalenol

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Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines.

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Goniothalenol Chemical Structure

CAS No. : 65408-91-5

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Description

Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	19 μM Compound: 6	Antiproliferative activity against human CEM cells after 48 hrs by SRB assay Antiproliferative activity against human CEM cells after 48 hrs by SRB assay	[PMID: 20036566]
L1210	IC₅₀	2.9 μg/mL Compound: 1	Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay	[PMID: 10479313]
MCF-12A	IC₅₀	120 μM Compound: 6	Cytotoxicity against human MCF12A cells after 48 hrs by SRB assay Cytotoxicity against human MCF12A cells after 48 hrs by SRB assay	[PMID: 20036566]
MCF7	IC₅₀	124 μM Compound: 6	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 20036566]
RAW264.7	IC₅₀	0.8 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23735825]
RAW264.7	IC₅₀	0.8 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IFN-beta mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IFN-beta mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	0.9 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-6 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-6 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	2 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	3 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	3 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	4 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced G-CSF mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced G-CSF mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	4 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced MCP1 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced MCP1 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	43.4 μM Compound: 2	Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay	[PMID: 23735825]
RAW264.7	IC₅₀	5 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IP-10 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IP-10 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	6.7 μM Compound: 2	Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay	[PMID: 23735825]

Molecular Weight

232.23

Formula

C₁₃H₁₂O₄

CAS No.

65408-91-5

SMILES

O[C@@H]1[C@@H](C2=CC=CC=C2)O[C@]3([H])[C@@]1([H])OC(C=C3)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang, Y. J., et al. Styryllactones from the Rhizomes ofGoniothalamus griffithii. Journal of Asian Natural Products Research, 1(3), 189–197.

Goniothalenol Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Goniothalenol65408-91-5OthersStyryl lactoneGoniothalamus griffithiiCytatoxic activitiesA2780HCT-8KBMCF-7Inhibitorinhibitorinhibit

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