2. Anti-infection
  3. HIV
  4. gp120-IN-2

gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells.

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gp120-IN-2 Chemical Structure

gp120-IN-2 Chemical Structure

CAS No. : 123629-42-5

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gp120-IN-2 Related Antibodies

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Description

gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells[1].

IC50 & Target[1]

HIV-1

7.5 μM (IC50)

HIV-1

112.93 μM (CC50)

Cellular Effect
Cell Line Type Value Description References
786-0 GI50
17.5 μg/mL
Compound: BA20
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
HT-29 GI50
28.1 μg/mL
Compound: BA20
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
NCI/ADR-RES GI50
0.25 μg/mL
Compound: BA20
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
NCI-H460 GI50
125.6 μg/mL
Compound: BA20
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
OVCAR-3 GI50
1.7 μg/mL
Compound: BA20
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
PC-3 GI50
46.3 μg/mL
Compound: BA20
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
SUP-T1 CC50
140.97 μM
Compound: 4l
Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay
Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay
[PMID: 34839157]
U-251 GI50
4.5 μg/mL
Compound: BA20
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
Molecular Weight

306.31

Formula

C15H18N2O5
CAS No.
SMILES

CCOC(C1=C(NC(NC1C2=CC(OC)=C(C=C2)O)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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gp120-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

gp120-IN-2123629-42-5HIVHuman immunodeficiency virusSupT1 cellslow cytotoxicityanti-HIV-1HL2/3dose-dependentInhibitorinhibitorinhibit

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